Results 181 to 190 of about 423,064 (316)

In silico analysis of patient specific coagulation and flow effects on fibrin clot formation. [PDF]

Sci Rep
Cruts JMH, Rezaeimoghaddam M, Rachid A, Bontempi L, Arisz RA, van de Vosse FN, Gijsen FJH.   +6 more
europepmc   +1 more source

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

A three-dimensional and multivariate statistical analysis of serine-hydrolases active sites.

, 2012
EBERT, CYNTHIA, FOSCATO, MARCO, GARDOSSI, Lucia, FERRARIO, VALERIO   +3 more
core  

Safety Assessment of <i>Sophora flavescens</i> Root Extract for Cosmetic Use: An Integrated Approach Using In Vitro, In Silico MoS, TTC, and History of Safe Use. [PDF]

Toxics
Gil S, Lee H, Lee SH, Shin SA, Choi DW, Lim KM.   +5 more
europepmc   +1 more source

PhosSight: A Unified Deep Learning Framework Boosting and Accelerating Phosphoproteome Identification to Enable Biological Discoveries

Advanced Science, EarlyView.
PhosSight is a unified deep‐learning framework for phosphoproteome identification, featured by a phosphorylation‐aware detectability predictor. It improves identification sensitivity in DDA through deep re‐localization and rescoring, accelerates DIA searches by detectability‐guided spectral library pruning, and expands phosphoproteome coverage to ...
Ben Wang, Zhiyuan Cheng, Chengying She, Hongwei Zhao, Jiahui Zhang, Lin Lv, Zhihao Yan, Hongwen Zhu, Lizhuang Liu, Yan Fu, Xinpei Yi   +10 more
wiley   +1 more source

Conformational changes of lipases: a comparative study and experimental implications

, 2012
EBERT, CYNTHIA, FATTOR, DIANA, FOSCATO, MARCO, GARDOSSI, Lucia, FERRARIO, VALERIO, KNAPIC, Lorena   +5 more
core  

Types of genotypes in progressive familial intrahepatic cholestasis and liver transplantation: A meta-analysis of observational studies. [PDF]

PLoS One
Sakka R, Abroug H, Youssef SB, Mekki M, M'rad R.   +4 more
europepmc   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

3D analysis of catalytic differences of hydrolases by integrating modelling and mutivariate statistics

, 2012
EBERT, CYNTHIA, FOSCATO, MARCO, GARDOSSI, Lucia, FERRARIO, VALERIO, Svendsen, A., KNAPIC, Lorena, Besenmatter, W.   +6 more
core  

Comprehensive Taste Profile Assessment of Underexplored Amino Acids and Protein Derivatives in Umami and Koku. [PDF]

Foods
López Martínez MI, Hopf A, Salvador A, Toldrá F, Forde C, Mora L.   +5 more
europepmc   +1 more source