Results 251 to 260 of about 167,809 (296)

Microrobotic Catheterization of the Ophthalmic Artery for Targeted Treatment of Retinoblastoma

Advanced Intelligent Systems, EarlyView.
A microrobotic platform is presented that allows teleoperated and autonomous navigation of flow‐driven magnetic microcatheters, MagFlow, into the ophthalmic artery for superselective intra‐arterial infusion of chemotherapy to treat retinoblastoma. Extensive benchtop validations with patient‐derived biomimetic phantoms under optical and fluoroscopic ...
Artur Banach, Mehdi Krichen, Julian Raub, Christina Stathopoulos, Bruno Bartolini, Mahmut Selman Sakar   +5 more
wiley   +1 more source

In silico modeling for ex vivo placenta perfusion of nicotine. [PDF]

Front Pharmacol
Ho H, Zhang S, Kurosawa K, Jiang B, Chiba K.   +4 more
europepmc   +1 more source

Machine Learning‐Driven Digital Twin of a Field‐Effect Transistor‐Based Hormone Biosensor for Real‐Time Estradiol Monitoring

Advanced Intelligent Systems, EarlyView.
A machine learning‐driven digital twin simulates an aptamer‐functionalized BioFET measuring 17β‐estradiol. Real‐time Isd signals are processed, features are extracted, and trained models estimate hormone concentration. In parallel, a one‐step‐ahead forward model learns biosensor dynamics and generates realistic synthetic signals, enabling in silico ...
Anastasiia Gorelova, Alexandra Parichenko, Shirong Huang, Santiago Melia, Gianaurelio Cuniberti   +4 more
wiley   +1 more source

Synthesis, Glucosidase Inhibition, and In Silico Modeling Analysis of Highly Fluorinated 2-Imino-1,3-thiazolines in Search of Potent Antidiabetic Agents. [PDF]

ACS Omega
Zahid LU, Zaib S, Saeed A, Alharbi HY, Aljohani MS, Alharbi O, Rana N, Khan I, Shabir G, Ahmed A, Saleem A, Awwad NS, Ibrahium HA.   +12 more
europepmc   +1 more source

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In Silico Models for Hepatotoxicity

2022
In this chapter, we review the state of the art of predicting human hepatotoxicity using in silico techniques. There has been significant progress in this area over the past 20 years but there are still some challenges ahead. Principally, these challenges are our partial understanding of a very complex biochemical system and our ability to emulate that
Claire, Ellison, Mark, Hewitt, Katarzyna, Przybylak   +2 more
openaire   +2 more sources

Towards in silico Process Modeling for Vaccines

Trends in Biotechnology, 2021
Chemical, manufacturing, and control development timelines occupy a significant part of vaccine end-to-end development. In the on-going race for accelerating timelines, in silico process development constitutes a viable strategy that can be achieved through an artificial intelligence (AI)-driven or a mechanistically oriented approach.
Antonio Gaetano Cardillo, Moritz von Stosch, Christos Varsakelis   +2 more
exaly   +3 more sources

In silico modeling of asthma

Advanced Drug Delivery Reviews, 2003
The incidence of asthma is increasing throughout the world, especially among children, to the extent that it has become a medical issue of serious global concern. Appropriately, numerous pharmacologic drugs and clinical protocols for the treatment and prophylaxis of the disease have been reported.
Martonen, Ted, Fleming, John, Schroeter, Jeffrey, Conway, Joy, Hwang, Dongming   +4 more
openaire   +3 more sources

In Silico Models for Developmental Toxicity

2022
Modeling developmental toxicity has been a challenge for (Q)SAR model developers due to the complexity of the endpoint. Recently, some new in silico methods have been developed introducing the possibility to evaluate the integration of existing methods by taking advantage of various modeling perspectives. It is important that the model user is aware of
Marco, Marzo, Alessandra, Roncaglioni, Sunil, Kulkarni, Tara S, Barton-Maclaren, Emilio, Benfenati   +4 more
openaire   +2 more sources