Results 1 to 10 of about 321,930 (219)
Scientific Reports, 2022 Standing radiographs play an important role in the characterization of spinal sagittal alignment, as they depict the spine under physiologic loading conditions.
Benjamin Hajnal +6 more
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Frontiers in Neuroscience, 2021 CNS disorders are lagging behind other indications in implementing genotype-dependent treatment algorithms for personalized medicine. This report uses a biophysically realistic computer model of an associative and dorsal motor cortico-striatal-thalamo ...
Athan Spiros, Hugo Geerts, Hugo Geerts
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Alzheimer’s Research & Therapy, 2018 Background Despite a tremendous amount of information on the role of amyloid in Alzheimer’s disease (AD), almost all clinical trials testing this hypothesis have failed to generate clinically relevant cognitive effects.
Hugo Geerts +2 more
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lazar: A modular predictive toxicology framework
Frontiers in Pharmacology, 2013 lazar (lazy structure-activity relationships) is a modular framework for predictive toxicology. Similar to the read across procedure in toxicological risk assessment, lazar creates local QSAR models for each compound to be predicted. Model developers can
Andreas eMaunz +5 more
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Frontiers in Pharmacology, 2013 Successful disease-modifying drug development for Alzheimer’s disease has hit a roadblock with the recent failures of amyloid-based therapies, highlighting the translational disconnect between preclinical animal models and clinical outcome.
Hugo eGeerts +5 more
doaj +1 more source
Scientific Reports, 2023 Total en bloc spondylectomy (TES) effectively treats spinal tumors. The surgery requires a vertebral body replacement (VBR), for which several solutions were developed, whereas the biomechanical differences between these devices still need to be ...
Agoston Jakab Pokorni +4 more
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Frontiers in Pharmacology, 2016 The current treatment of Parkinson’s disease with dopamine-centric approaches such as L-DOPA and dopamine agonists, although very succesfull, is in need of alternative treatment strategies, both in terms of disease modification and symptom management ...
Hugo eGeerts +4 more
doaj +1 more source
Frontiers in Pharmacology, 2014 Although many antipsychotics can reasonably control positive symptoms in schizophrenia, patients’ return to society is often hindered by negative symptoms and cognitive deficits.
Hugo eGeerts +4 more
doaj +1 more source
Frontiers in Pharmacology, 2015 While many drug discovery research programs aim to develop highly selective clinical candidates, their clinical success is limited because of the complex non-linear interactions of human brain neuronal circuits.
Hugo eGeerts +4 more
doaj +1 more source
Cancer Informatics, 2016 The plethora of available disease prediction models and the ongoing process of their application into clinical practice – following their clinical validation – have created new needs regarding their efficient handling and exploitation.
Nikolaos A. Christodoulou +5 more
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