Results 1 to 10 of about 700,727 (353)
In silico workflow for validation of patient-specific 3D-printed casts in forearm fracture immobilization [PDF]
Frontiers in SurgeryBackgroundThis paper aims to establish an in silico workflow for biomechanical assessment of patient-specific 3D-printed forearm casts using finite element analysis, and to apply this workflow to compare a novel computationally designed point-of-care ...
Marton Bartos +15 more
doaj +2 more sources
Journal of Chemical Theory and Computation, 2021 Many important processes affecting the earth's climate are determined by the physical properties of seawater. In addition, desalination of seawater is a significant source of drinking water for the human population living in coastal areas. Since the physical properties of seawater governing these processes depend on the molecular interactions among its
Ivan M. Zeron +4 more
openaire +5 more sources
Orvosi Hetilap, 2016 Introduction: Simulation models can contribute substantially to our understanding and ability to control the dynamic processes underlying impaired glucose metabolism in diabetic patients. Aim: The aim of this paper is to outline a new comprehensive, physiologically-based dynamic model of glucose homeostasis incorporating up-to-date quantitative ...
DiĂł, MihĂĄly +2 more
openaire +3 more sources
Combined In Silico, In Vivo, and In Vitro Studies Shed Insights into the Acute Inflammatory Response in Middle-Aged Mice [PDF]
, 2013 We combined in silico, in vivo, and in vitro studies to gain insights into age-dependent changes in acute inflammation in response to bacterial endotoxin (LPS). Time-course cytokine, chemokine, and NO2-/NO3- data from "middle-aged" (6-8 months old) C57BL/
A Torres +63 more
core +9 more sources
Scientific Reports, 2022 Standing radiographs play an important role in the characterization of spinal sagittal alignment, as they depict the spine under physiologic loading conditions.
Benjamin Hajnal +6 more
doaj +1 more source
Frontiers in Neuroscience, 2021 CNS disorders are lagging behind other indications in implementing genotype-dependent treatment algorithms for personalized medicine. This report uses a biophysically realistic computer model of an associative and dorsal motor cortico-striatal-thalamo ...
Athan Spiros, Hugo Geerts, Hugo Geerts
doaj +1 more source
Alzheimer’s Research & Therapy, 2018 Background Despite a tremendous amount of information on the role of amyloid in Alzheimer’s disease (AD), almost all clinical trials testing this hypothesis have failed to generate clinically relevant cognitive effects.
Hugo Geerts +2 more
doaj +1 more source
lazar: A modular predictive toxicology framework
Frontiers in Pharmacology, 2013 lazar (lazy structure-activity relationships) is a modular framework for predictive toxicology. Similar to the read across procedure in toxicological risk assessment, lazar creates local QSAR models for each compound to be predicted. Model developers can
Andreas eMaunz +5 more
doaj +1 more source
Predicting optimal hematocrit in silico [PDF]
, 2018 Optimal hematocrit $H_o$ maximizes oxygen transport. In healthy humans, the average hematocrit $H$ is in the range of 40-45$\%$, but it can significantly change in blood pathologies such as severe anemia (low $H$) and polycythemia (high $H$). Whether the
Audemar, Vassanti +11 more
core +7 more sources
Frontiers in Pharmacology, 2013 Successful disease-modifying drug development for Alzheimer’s disease has hit a roadblock with the recent failures of amyloid-based therapies, highlighting the translational disconnect between preclinical animal models and clinical outcome.
Hugo eGeerts +5 more
doaj +1 more source