Results 41 to 50 of about 309,952 (268)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Whole genome sequence of petroleum hydrocarbon degrading novel strain Microbacter sp. EMBS2025 isolated from Chilika Lake, Odisha, India

Scientific Reports
Bioremediation offers a sustainable and eco-friendly approach for addressing petroleum contamination. In this study, we investigated the hydrocarbon-degrading potential of Microbacter sp.
Anuraj Nayarisseri, Khushboo Sharma, Arshiya Khan, Radhika Swami, Rinku Chaudhary, Juhi Sharma, Navpreet Kaur, Jyotsana Kharate, Vasudha Rathore, Leena Prajapati, Srinivas Bandaru, Francisco Jaime Bezerra Mendonça Junior, Marcus T. Scotti, Luciana Scotti   +13 more
doaj   +1 more source

Surfactant-free gelatin-stabilised biodegradable polymerised high internal phase emulsions with macroporous structures

Frontiers in Chemistry, 2023
High internal phase emulsion (HIPE) templating is a well-established method for the generation of polymeric materials with high porosity (>74%) and degree of interconnectivity.
Rachel Furmidge, Rachel Furmidge, Caitlin E. Jackson, Caitlin E. Jackson, María Fernanda Velázquez de la Paz, María Fernanda Velázquez de la Paz, Victoria L. Workman, Victoria L. Workman, Nicola H. Green, Nicola H. Green, Gwendolen C. Reilly, Gwendolen C. Reilly, Vanessa Hearnden, Vanessa Hearnden, Frederik Claeyssens, Frederik Claeyssens   +15 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Numerical simulation of waste landfill biodegradation: Fitting experimental data

Dyna
Landfill remains economically viable for the disposal of Municipal Solid Waste (MSW), however, experiences of failure in several Colombian and global locations, lead to soil, water, and air pollution, harming ecosystems, and biodiversity.
Vladimir Buelvas-Hernandez, Juliana Lucía Moreno-Medina, Marcela Mercado-Montoya   +2 more
doaj   +1 more source

Author Correction: Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail

Scientific Reports, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Marwa M. Mahmoud, Jovana Serbanovic-Canic, Shuang Feng, Celine Souilhol, Rouyu Xing, Sarah Hsiao, Akiko Mammoto, Jing Chen, Markus Ariaans, Sheila E. Francis, Kim Van der Heiden, Victoria Ridger, Paul C. Evans   +12 more
doaj   +1 more source

Associations between Physical Exercise, Quality of Life, Psychological Symptoms and Treatment Side Effects in Early Breast Cancer

The Breast Journal, 2022
Background. Identifying and understanding modifiable factors for the well-being of cancer patients is critical in survivorship research. We studied variables associated with the exercise habits of breast cancer patients and investigated if the ...
Leena Vehmanen, Johanna Mattson, Evangelos Karademas, Albino J. Oliveira-Maia, Berta Sousa, Ruth Pat-Horenczyk, Ketti Mazzocco, Panagiotis Simos, Fátima Cardoso, Greta Pettini, Chiara Marzorati, Eleni Kolokotroni, Georgios Stamatakos, Diana Frasquilho, Paula Poikonen-Saksela   +14 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Improving route development using convergent retrosynthesis planning

Journal of Cheminformatics
Retrosynthesis consists of recursively breaking down a target molecule to produce a synthesis route composed of readily accessible building blocks. In recent years, computer-aided synthesis planning methods have allowed a greater exploration of potential
Paula Torren-Peraire, Jonas Verhoeven, Dorota Herman, Hugo Ceulemans, Igor V. Tetko, Jörg K. Wegner   +5 more
doaj   +1 more source

In silico toxicology protocols

Regulatory Toxicology and Pharmacology, 2018
The present publication surveys several applications of in silico (i.e., computational) toxicology approaches across different industries and institutions. It highlights the need to develop standardized protocols when conducting toxicity-related predictions.
Myatt, Glenn J., Ahlberg, Ernst, Akahori, Yumi, Allen, David, Amberg, Alexander, Anger, Lennart T., Aptula, Aynur, Auerbach, Scott, Beilke, Lisa, Bellion, Phillip, Benigni, Romualdo, Bercu, Joel, Booth, Ewan D., Bower, Dave, Brigo, Alessandro, Burden, Natalie, Cammerer, Zoryana, Cronin, Mark T.D., Cross, Kevin P., Custer, Laura, Dettwiler, Magdalena, Dobo, Krista, Ford, Kevin A., Fortin, Marie C., Gad-McDonald, Samantha E., Gellatly, Nichola, Gervais, Véronique, Glover, Kyle P., Glowienke, Susanne, Van Gompel, Jacky, Gutsell, Steve, Hardy, Barry, Harvey, James S., Hillegass, Jedd, Honma, Masamitsu, Hsieh, Jui Hua, Hsu, Chia Wen, Hughes, Kathy, Johnson, Candice, Jolly, Robert, Jones, David, Kemper, Ray, Kenyon, Michelle O., Kim, Marlene T., Kruhlak, Naomi L., Kulkarni, Sunil A., Kümmerer, Klaus, Leavitt, Penny, Majer, Bernhard, Masten, Scott, Miller, Scott, Moser, Janet, Mumtaz, Moiz, Muster, Wolfgang, Neilson, Louise, Oprea, Tudor I., Patlewicz, Grace, Paulino, Alexandre, Lo Piparo, Elena, Powley, Mark, Quigley, Donald P., Reddy, M. Vijayaraj, Richarz, Andrea Nicole, Ruiz, Patricia, Schilter, Benoit, Serafimova, Rositsa, Simpson, Wendy, Stavitskaya, Lidiya, Stidl, Reinhard, Suarez-Rodriguez, Diana, Szabo, David T., Teasdale, Andrew, Trejo-Martin, Alejandra, Valentin, Jean Pierre, Vuorinen, Anna, Wall, Brian A., Watts, Pete, White, Angela T., Wichard, Joerg, Witt, Kristine L., Woolley, Adam, Woolley, David, Zwickl, Craig, Hasselgren, Catrin   +83 more
openaire   +2 more sources