Results 51 to 60 of about 423,064 (316)
, 2014 In silico tree with tips renamed to full species ...
Brant C. Faircloth (143432) +7 more
core +1 more source
3D kernel-density stochastic model for more personalized glycaemic control: development and in-silico validation [PDF]
, 2019 peer reviewedBackground: The challenges of glycaemic control in critically ill patients have been debated for 20 years. While glycaemic control shows benefits, inter- and intra-patient metabolic variability results in increased hypoglycaemia and ...
Uyttendaele, Vincent +6 more
core +1 more source
Small ScienceSmall molecules that target RNA are emerging as a powerful therapeutic modality, although deriving structure–activity relationships (SARs) remains a major challenge.
Haruhiko Hattori +6 more
doaj +1 more source
Perspectives of tissues in silico
EXCLI journal, 2015 EXCLI Journal; 14:Doc408; ISSN 1611 ...
Hammad, Seddik +3 more
openaire +3 more sources
Protein aggregation in silico [PDF]
Trends in Biotechnology, 2007 Protein aggregation is a challenge to the successful manufacture of protein therapeutics; it can impose severe limitations on purification yields and compromise formulation stability. Advances in computer power, and the wealth of computational studies pertaining to protein folding, have facilitated the development of molecular simulation as a tool to ...
Troy, Cellmer +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Frontiers in Bioengineering and Biotechnology, 2021 Introduction: In developed countries, the age structure of the population is currently undergoing an upward shift, resulting a decrease in general bone quality and surgical durability. Over the past decade, oblique lumbar interbody fusion (OLIF) has been
Ferenc Bereczki +8 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
in-silico-uce-probes-to-contigs.lastz.tar.gz
, 2014 LASTZ files showing mapping of UCE probes onto in silico genome slices AND probe.matches.sqlite ...
Brant C. Faircloth (143432) +7 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source