Results 21 to 30 of about 423,064 (316)

A HUMANIZED CLINICALLY CALIBRATED QUANTITATIVE SYSTEMS PHARMACOLOGY MODEL FOR HYPOKINETIC MOTOR SYMPTOMS IN PARKINSON’S DISEASE

Frontiers in Pharmacology, 2016
The current treatment of Parkinson’s disease with dopamine-centric approaches such as L-DOPA and dopamine agonists, although very succesfull, is in need of alternative treatment strategies, both in terms of disease modification and symptom management ...
Hugo eGeerts, Hugo eGeerts, Patrick eRoberts, Patrick eRoberts, Athan eSpiros   +4 more
doaj   +1 more source

Negative Symptoms in Schizophrenia: Exploring Glutamatergic Modulation Using a Computer-Based Quantitative Systems Pharmacology Approach

Frontiers in Pharmacology, 2014
Although many antipsychotics can reasonably control positive symptoms in schizophrenia, patients’ return to society is often hindered by negative symptoms and cognitive deficits.
Hugo eGeerts, Hugo eGeerts, Athan eSpiros, Patrick eRoberts, Patrick eRoberts   +4 more
doaj   +1 more source

Assessing the synergy between cholinomimetics and memantine as augmentation therapy in Cognitive Impairment in Schizophrenia. A virtual human patient trial using Quantitative Systems Pharmacology

Frontiers in Pharmacology, 2015
While many drug discovery research programs aim to develop highly selective clinical candidates, their clinical success is limited because of the complex non-linear interactions of human brain neuronal circuits.
Hugo eGeerts, Hugo eGeerts, Athan eSpiros, Patrick eRoberts, Patrick eRoberts   +4 more
doaj   +1 more source

Insulin sensitivity in critically ill patients: are women more insulin resistant?

Annals of Intensive Care, 2021
Background Glycaemic control (GC) in intensive care unit is challenging due to significant inter- and intra-patient variability, leading to increased risk of hypoglycaemia. Recent work showed higher insulin resistance in female preterm neonates.
Vincent Uyttendaele, J. Geoffrey Chase, Jennifer L. Knopp, Rebecca Gottlieb, Geoffrey M. Shaw, Thomas Desaive   +5 more
doaj   +1 more source

How can we discover developable antibody-based biotherapeutics?

Frontiers in Molecular Biosciences, 2023
Antibody-based biotherapeutics have emerged as a successful class of pharmaceuticals despite significant challenges and risks to their discovery and development.
Joschka Bauer, Joschka Bauer, Nandhini Rajagopal, Nandhini Rajagopal, Priyanka Gupta, Priyanka Gupta, Pankaj Gupta, Pankaj Gupta, Andrew E. Nixon, Sandeep Kumar, Sandeep Kumar   +10 more
doaj   +1 more source

The acceptance of in silico models for REACH: Requirements, barriers, and perspectives [PDF]

, 2011
In silico models have prompted considerable interest and debate because of their potential value in predicting the properties of chemical substances for regulatory purposes.
Antonio Cassano, R. Gonella Diaza, Giuseppina Gini, Simon Pardoe, Rodolfo Gonella Diaza, Rodolfo Diaza, Knauf Ralf, Pardoe, Simon, Benighaus, Ludger, L. Benighaus, Cassano Antonio, A. Cassano, E. Benfenati, Mays, Claire, S. Pardoe, C. Mays, Ludger Benighaus, R. Knauf, Ralf Knauf, Benighaus Ludger, Gini Giuseppina, Emilio Benfenati, Knauf, Ralf, Claire Mays, Mays Claire, Benfenati Emilio, Gini, Giuseppina, Diaza Rodolfo, Gonella Diaza, Rodolfo, Cassano, Antonio, Benfenati, Emilio, Pardoe Simon   +31 more
core   +1 more source

A Modular Repository-based Infrastructure for Simulation Model Storage and Execution Support in the Context of Oncology and Medicine

Cancer Informatics, 2016
The plethora of available disease prediction models and the ongoing process of their application into clinical practice – following their clinical validation – have created new needs regarding their efficient handling and exploitation.
Nikolaos A. Christodoulou, Nikolaos E. Tousert, Eleni Ch. Georgiadi, Katerina D. Argyri, Fay D. Misichroni, Georgios S. Stamatakos   +5 more
doaj   +1 more source

TeachOpenCADD: a teaching platform for computer-aided drug design using open source packages and data

Journal of Cheminformatics, 2019
Owing to the increase in freely available software and data for cheminformatics and structural bioinformatics, research for computer-aided drug design (CADD) is more and more built on modular, reproducible, and easy-to-share pipelines.
Dominique Sydow, Andrea Morger, Maximilian Driller, Andrea Volkamer   +3 more
doaj   +1 more source

Reducing the Complexity of Musculoskeletal Models Using Gaussian Process Emulators

Applied Sciences, 2022
Musculoskeletal models (MSKMs) are used to estimate the muscle and joint forces involved in human locomotion, often associated with the onset of degenerative musculoskeletal pathologies (e.g., osteoarthritis).
Ivan Benemerito, Erica Montefiori, Alberto Marzo, Claudia Mazzà   +3 more
doaj   +1 more source

In Silico Studies on DARC

Infectious Disorders - Drug Targets, 2009
The Duffy Antigen/Receptor for Chemokine (DARC) is a seven segment transmembrane protein. It was firstly discovered as a blood group antigen and was the first specific gene locus assigned to a specific autosome in man. It became more famous as an erythrocyte receptor for malaria parasites (Plasmodium vivax and Plasmodium knowlesi), and finally for ...
de Brevern, Alexandre, Autin, Ludovic, Colin, Yves, Bertrand, Olivier, Etchebest, Catherine   +4 more
openaire   +4 more sources