Results 11 to 20 of about 700,727 (353)
Scientific Reports, 2023 Total en bloc spondylectomy (TES) effectively treats spinal tumors. The surgery requires a vertebral body replacement (VBR), for which several solutions were developed, whereas the biomechanical differences between these devices still need to be ...
Agoston Jakab Pokorni +4 more
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Frontiers in Pharmacology, 2016 The current treatment of Parkinson’s disease with dopamine-centric approaches such as L-DOPA and dopamine agonists, although very succesfull, is in need of alternative treatment strategies, both in terms of disease modification and symptom management ...
Hugo eGeerts +4 more
doaj +1 more source
Comprehensive comparison of in silico MS/MS fragmentation tools of the CASMI contest: database boosting is needed to achieve 93% accuracy. [PDF]
, 2017 In mass spectrometry-based untargeted metabolomics, rarely more than 30% of the compounds are identified. Without the true identity of these molecules it is impossible to draw conclusions about the biological mechanisms, pathway relationships and ...
Biedendieck, Rebekka +11 more
core +2 more sources
Frontiers in Pharmacology, 2014 Although many antipsychotics can reasonably control positive symptoms in schizophrenia, patients’ return to society is often hindered by negative symptoms and cognitive deficits.
Hugo eGeerts +4 more
doaj +1 more source
In silico evolution of diauxic growth [PDF]
, 2015 The glucose effect is a well known phenomenon whereby cells, when presented with two different nutrients, show a diauxic growth pattern, i.e. an episode of exponential growth followed by a lag phase of reduced growth followed by a second phase of ...
A Bennett +37 more
core +1 more source
Frontiers in Pharmacology, 2015 While many drug discovery research programs aim to develop highly selective clinical candidates, their clinical success is limited because of the complex non-linear interactions of human brain neuronal circuits.
Hugo eGeerts +4 more
doaj +1 more source
Insulin sensitivity in critically ill patients: are women more insulin resistant?
Annals of Intensive Care, 2021 Background Glycaemic control (GC) in intensive care unit is challenging due to significant inter- and intra-patient variability, leading to increased risk of hypoglycaemia. Recent work showed higher insulin resistance in female preterm neonates.
Vincent Uyttendaele +5 more
doaj +1 more source
How can we discover developable antibody-based biotherapeutics?
Frontiers in Molecular Biosciences, 2023 Antibody-based biotherapeutics have emerged as a successful class of pharmaceuticals despite significant challenges and risks to their discovery and development.
Joschka Bauer +10 more
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Protein aggregation in silico [PDF]
Trends in Biotechnology, 2007 Protein aggregation is a challenge to the successful manufacture of protein therapeutics; it can impose severe limitations on purification yields and compromise formulation stability. Advances in computer power, and the wealth of computational studies pertaining to protein folding, have facilitated the development of molecular simulation as a tool to ...
Troy, Cellmer +3 more
openaire +2 more sources
Journal of Cheminformatics, 2019 Owing to the increase in freely available software and data for cheminformatics and structural bioinformatics, research for computer-aided drug design (CADD) is more and more built on modular, reproducible, and easy-to-share pipelines.
Dominique Sydow +3 more
doaj +1 more source