Results 11 to 20 of about 309,952 (268)
Frontiers in Pharmacology, 2014 Although many antipsychotics can reasonably control positive symptoms in schizophrenia, patients’ return to society is often hindered by negative symptoms and cognitive deficits.
Hugo eGeerts +4 more
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Frontiers in Pharmacology, 2015 While many drug discovery research programs aim to develop highly selective clinical candidates, their clinical success is limited because of the complex non-linear interactions of human brain neuronal circuits.
Hugo eGeerts +4 more
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Cancer Informatics, 2016 The plethora of available disease prediction models and the ongoing process of their application into clinical practice – following their clinical validation – have created new needs regarding their efficient handling and exploitation.
Nikolaos A. Christodoulou +5 more
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Journal of Cheminformatics, 2019 Owing to the increase in freely available software and data for cheminformatics and structural bioinformatics, research for computer-aided drug design (CADD) is more and more built on modular, reproducible, and easy-to-share pipelines.
Dominique Sydow +3 more
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Insulin sensitivity in critically ill patients: are women more insulin resistant?
Annals of Intensive Care, 2021 Background Glycaemic control (GC) in intensive care unit is challenging due to significant inter- and intra-patient variability, leading to increased risk of hypoglycaemia. Recent work showed higher insulin resistance in female preterm neonates.
Vincent Uyttendaele +5 more
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How can we discover developable antibody-based biotherapeutics?
Frontiers in Molecular Biosciences, 2023 Antibody-based biotherapeutics have emerged as a successful class of pharmaceuticals despite significant challenges and risks to their discovery and development.
Joschka Bauer +10 more
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Infectious Disorders - Drug Targets, 2009 The Duffy Antigen/Receptor for Chemokine (DARC) is a seven segment transmembrane protein. It was firstly discovered as a blood group antigen and was the first specific gene locus assigned to a specific autosome in man. It became more famous as an erythrocyte receptor for malaria parasites (Plasmodium vivax and Plasmodium knowlesi), and finally for ...
de Brevern, Alexandre +4 more
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Reducing the Complexity of Musculoskeletal Models Using Gaussian Process Emulators
Applied Sciences, 2022 Musculoskeletal models (MSKMs) are used to estimate the muscle and joint forces involved in human locomotion, often associated with the onset of degenerative musculoskeletal pathologies (e.g., osteoarthritis).
Ivan Benemerito +3 more
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Educational Media Reviews Online, 2023 Distributed by Collective Eye Films, 1315 SE 20th Ave. #3, Portland OR 97214; 971-236-2056Produced by Kellen Quinn, Taylor Hess, and Jesse MillerDirected by Noah Hutton2020, Streaming, 83 mins In Silico chronicles the ten-year project to create a digital simulacrum of a human brain and the fortunes and foibles accompanying such a grandiose and ...
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Global reactivity models are impactful in industrial synthesis applications
Journal of Cheminformatics, 2023 Artificial Intelligence is revolutionizing many aspects of the pharmaceutical industry. Deep learning models are now routinely applied to guide drug discovery projects leading to faster and improved findings, but there are still many tasks with enormous ...
Paulo Neves +8 more
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