Results 11 to 20 of about 423,064 (316)
Genome Biology, 2008 A report of the 6th Georgia Tech-Oak Ridge National Lab International Conference on Bioinformatics 'In silico Biology: Gene Discovery and Systems Genomics', Atlanta, USA, 15-17 November, 2007.
Weng, Zhiping, Guigó, Roderic
openaire +6 more sources
Journal of Chemical Theory and Computation, 2021 Many important processes affecting the Earth's climate are determined by the physical properties of seawater. Desalination of seawater is a significant source of drinking wate.Since the physical properties of seawater governing these processes depend on the molecular interactions among its components, a deeper knowledge of seawater at the molecular ...
Zeron, Ivan M. +4 more
openaire +5 more sources
Orvosi Hetilap, 2016 Introduction: Simulation models can contribute substantially to our understanding and ability to control the dynamic processes underlying impaired glucose metabolism in diabetic patients. Aim: The aim of this paper is to outline a new comprehensive, physiologically-based dynamic model of glucose homeostasis incorporating up-to-date quantitative ...
DiĂł, MihĂĄly +2 more
openaire +3 more sources
In silico pK a prediction [PDF]
Journal of Cheminformatics, 2012 The biopharmaceutical profile of a compound depends directly on the dissociation constants of its acidic and basic groups, commonly expressed as the negative decadic logarithm pKa of the acid dissociation constant (Ka). The acid dissociation constant (also protonation or ionization constant) Ka is an equilibrium constant defined as the ratio of the ...
Robert Körner +3 more
openaire +1 more source
Scientific Reports, 2022 Standing radiographs play an important role in the characterization of spinal sagittal alignment, as they depict the spine under physiologic loading conditions.
Benjamin Hajnal +6 more
doaj +1 more source
Frontiers in Neuroscience, 2021 CNS disorders are lagging behind other indications in implementing genotype-dependent treatment algorithms for personalized medicine. This report uses a biophysically realistic computer model of an associative and dorsal motor cortico-striatal-thalamo ...
Athan Spiros, Hugo Geerts, Hugo Geerts
doaj +1 more source
lazar: A modular predictive toxicology framework
Frontiers in Pharmacology, 2013 lazar (lazy structure-activity relationships) is a modular framework for predictive toxicology. Similar to the read across procedure in toxicological risk assessment, lazar creates local QSAR models for each compound to be predicted. Model developers can
Andreas eMaunz +5 more
doaj +1 more source
Frontiers in Pharmacology, 2013 Successful disease-modifying drug development for Alzheimer’s disease has hit a roadblock with the recent failures of amyloid-based therapies, highlighting the translational disconnect between preclinical animal models and clinical outcome.
Hugo eGeerts +5 more
doaj +1 more source
Alzheimer’s Research & Therapy, 2018 Background Despite a tremendous amount of information on the role of amyloid in Alzheimer’s disease (AD), almost all clinical trials testing this hypothesis have failed to generate clinically relevant cognitive effects.
Hugo Geerts +2 more
doaj +1 more source
Scientific Reports, 2023 Total en bloc spondylectomy (TES) effectively treats spinal tumors. The surgery requires a vertebral body replacement (VBR), for which several solutions were developed, whereas the biomechanical differences between these devices still need to be ...
Agoston Jakab Pokorni +4 more
doaj +1 more source