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Anti-Cancer Agents in Medicinal Chemistry, 2022
BACKGROUND We synthesized a series of novel amide derivatives of (5-((2-chloropyridin-4-yl)oxy)-3-phenyl-1H-pyrazol-1-yl)-2-(4-substituted phenyl)-N,N-dimethylethen-1-amine [5a-5r] and assessed for their antiproliferative activity against human breast ...
T. Panneerselvam +9 more
semanticscholar +1 more source
BACKGROUND We synthesized a series of novel amide derivatives of (5-((2-chloropyridin-4-yl)oxy)-3-phenyl-1H-pyrazol-1-yl)-2-(4-substituted phenyl)-N,N-dimethylethen-1-amine [5a-5r] and assessed for their antiproliferative activity against human breast ...
T. Panneerselvam +9 more
semanticscholar +1 more source
In Silico Models for Hepatotoxicity
2022In this chapter, we review the state of the art of predicting human hepatotoxicity using in silico techniques. There has been significant progress in this area over the past 20 years but there are still some challenges ahead. Principally, these challenges are our partial understanding of a very complex biochemical system and our ability to emulate that
Claire, Ellison +2 more
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Towards in silico Process Modeling for Vaccines.
Trends in Biotechnology, 2021Chemical, manufacturing, and control development timelines occupy a significant part of vaccine end-to-end development. In the on-going race for accelerating timelines, in silico process development constitutes a viable strategy that can be achieved through an artificial intelligence (AI)-driven or a mechanistically oriented approach.
Antonio Gaetano Cardillo +9 more
semanticscholar +3 more sources
In Silico Blood Pressure Models Comparison
IEEE Sensors Journal, 2022As cardiovascular diseases (CVDs) are one of the most prominent illnesses, continuous, noninvasive, and comfortable monitoring of blood pressure (BP) is indispensable. This article investigates the best method for obtaining highly accurate BP values in noninvasive measurements through the extraction of hemodynamic variables from the arteries of young ...
Ana Carolina Goncalves Seabra +3 more
openaire +3 more sources
Advanced Drug Delivery Reviews, 2003
The incidence of asthma is increasing throughout the world, especially among children, to the extent that it has become a medical issue of serious global concern. Appropriately, numerous pharmacologic drugs and clinical protocols for the treatment and prophylaxis of the disease have been reported.
Martonen, Ted +4 more
openaire +3 more sources
The incidence of asthma is increasing throughout the world, especially among children, to the extent that it has become a medical issue of serious global concern. Appropriately, numerous pharmacologic drugs and clinical protocols for the treatment and prophylaxis of the disease have been reported.
Martonen, Ted +4 more
openaire +3 more sources
In Silico Models for Hepatotoxicity
2016In this chapter we review the challenges of predicting human hepatotoxicity. Principally, this is our partial understanding of a very complex biochemical system and our ability to emulate that in a predictive capacity. We give an overview of the published modeling approaches in this area to date and discuss their design, strengths, and weaknesses.
Mark, Hewitt, Katarzyna, Przybylak
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In Silico Models for Developmental Toxicity
2022Modeling developmental toxicity has been a challenge for (Q)SAR model developers due to the complexity of the endpoint. Recently, some new in silico methods have been developed introducing the possibility to evaluate the integration of existing methods by taking advantage of various modeling perspectives. It is important that the model user is aware of
Marco, Marzo +4 more
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In silico modelling of physiologic systems
Best Practice & Research Clinical Anaesthesiology, 2011In silico modelling, in which computer models are developed to model a pharmacologic or physiologic process, is a logical extension of controlled in vitro experimentation. It is the natural result of the explosive increase in computing power available to the research scientist at continually decreasing cost.
Richard B, Colquitt +2 more
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Anisotropic Gold Nanostructures: Optimization via in Silico Modeling for Hyperthermia
ACS Applied Nano Materials, 2018Protein- and peptide-based manufacturing of self-assembled supramolecular functional materials has been a formidable challenge for biomedical applications, being complex in structure and immunogenic in nature.
Ajay-Vikram Singh +13 more
semanticscholar +1 more source