Results 251 to 260 of about 170,795 (287)
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In Silico Models for Hepatotoxicity
2022In this chapter, we review the state of the art of predicting human hepatotoxicity using in silico techniques. There has been significant progress in this area over the past 20 years but there are still some challenges ahead. Principally, these challenges are our partial understanding of a very complex biochemical system and our ability to emulate that
Claire, Ellison +2 more
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Advanced Drug Delivery Reviews, 2003
The incidence of asthma is increasing throughout the world, especially among children, to the extent that it has become a medical issue of serious global concern. Appropriately, numerous pharmacologic drugs and clinical protocols for the treatment and prophylaxis of the disease have been reported.
Martonen, Ted +4 more
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The incidence of asthma is increasing throughout the world, especially among children, to the extent that it has become a medical issue of serious global concern. Appropriately, numerous pharmacologic drugs and clinical protocols for the treatment and prophylaxis of the disease have been reported.
Martonen, Ted +4 more
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Frontiers in Cellular and Infection Microbiology, 2019 Mosquito-borne flaviviruses can cause disease in the nervous system, resulting in a significant burden of morbidity and mortality. Disease models are necessary to understand neuropathogenesis and identify potential therapeutics and vaccines.
Megan Chesnut +2 more
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In Silico Models for Developmental Toxicity
2022Modeling developmental toxicity has been a challenge for (Q)SAR model developers due to the complexity of the endpoint. Recently, some new in silico methods have been developed introducing the possibility to evaluate the integration of existing methods by taking advantage of various modeling perspectives. It is important that the model user is aware of
Marco, Marzo +4 more
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In Silico Models for Hepatotoxicity
2016In this chapter we review the challenges of predicting human hepatotoxicity. Principally, this is our partial understanding of a very complex biochemical system and our ability to emulate that in a predictive capacity. We give an overview of the published modeling approaches in this area to date and discuss their design, strengths, and weaknesses.
Mark, Hewitt, Katarzyna, Przybylak
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In silico modelling of physiologic systems
Best Practice & Research Clinical Anaesthesiology, 2011In silico modelling, in which computer models are developed to model a pharmacologic or physiologic process, is a logical extension of controlled in vitro experimentation. It is the natural result of the explosive increase in computing power available to the research scientist at continually decreasing cost.
Richard B, Colquitt +2 more
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In Silico Modeling of Crabtree Effect
Endocrine, Metabolic & Immune Disorders - Drug Targets, 2017Glycolytic activity during Crabtree effect is similar to that in tumor cells. Research regarding Crabtree effect is very much crucial.The mechanism of metabolic activities in glycolysis pathway and oxidative phosphorylation pathway in regards to Crabtree effect in Saccharomyces cerevisiae was studied in this paper.
Debraj, Ghosh, Rajat K, De
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A Hyperneuron Model Towards in Silico Implementation
International Journal of Bifurcation and Chaos, 2022In this paper, the concept of hyperneuron is introduced. The main properties and dynamical characteristics of this class of hypersystems will be studied by numerical analysis. The intrinsic robustness of the proposed model is further investigated by proposing a silicon implementation of the hyperneuron, reporting the corresponding experimental results.
Branciforte M., Buscarino A., Fortuna L.
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Towards in silico Process Modeling for Vaccines
Trends in Biotechnology, 2021Chemical, manufacturing, and control development timelines occupy a significant part of vaccine end-to-end development. In the on-going race for accelerating timelines, in silico process development constitutes a viable strategy that can be achieved through an artificial intelligence (AI)-driven or a mechanistically oriented approach.
Antonio Gaetano, Cardillo +9 more
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In Silico Blood Pressure Models Comparison
IEEE Sensors Journal, 2022As cardiovascular diseases (CVDs) are one of the most prominent illnesses, continuous, noninvasive, and comfortable monitoring of blood pressure (BP) is indispensable. This article investigates the best method for obtaining highly accurate BP values in noninvasive measurements through the extraction of hemodynamic variables from the arteries of young ...
Ana Carolina Goncalves Seabra +3 more
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