Results 61 to 70 of about 328,596 (315)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

In-situ SEM investigation on fracture behavior of GTD222 superalloy during tensile process at 760 °C

Journal of Materials Research and Technology, 2020
To characterize the fracture behaviors of the selective laser melting (SLM) processed GTD222 superalloy, in-situ scanning electron microscopy (SEM) observation was conducted during 760 °C tensile deformation.
Guoliang Zhu, Sitong Li, Rui Wang, Donghong Wang, Anping Dong, Da Shu, Liang Zhang, Baode Sun   +7 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

In situ observation of the percolation threshold in multiphase magma analogues

Bulletin of Volcanology, 2020
Magmas vesiculate during ascent, producing complex interconnected pore networks, which can act as outgassing pathways and then deflate or compact to volcanic plugs.
M. Colombier, F. Wadsworth, B. Scheu, J. Vasseur, K. Dobson, F. Cáceres, A. Allabar, F. Marone, C. Schlepütz, Donald Bruce Dingwell   +9 more
semanticscholar   +1 more source

In situ observation of biotite (001) surface dissolution at pH 1 and 9.5 by advanced optical microscopy

Beilstein Journal of Nanotechnology, 2015
Laser confocal differential interference contrast microscopy (LCM-DIM) allows for the study of the reactivity of surface minerals with slow dissolution rates (e.g., phyllosilicates).
Chiara Cappelli, Daniel Lamarca-Irisarri, Jordi Camas, F. Javier Huertas, Alexander E. S. Van Driessche   +4 more
doaj   +1 more source

On the Robustness of Annual Daily Precipitation Maxima Estimates Over Monsoon Asia

Frontiers in Climate, 2020
Understanding precipitation extremes over Monsoon Asia is vital for water resource management and hazard mitigation, but there are many gaps and uncertainties in observations in this region.
Phuong-Loan Nguyen, Margot Bador, Lisa V. Alexander, Todd P. Lane, Chris C. Funk, Chris C. Funk   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Ultrathin Bismuth Nanosheets for Stable Na-Ion Batteries: Clarification of Structure and Phase Transition by in Situ Observation.

Nano letters (Print), 2019
Bismuth has garnered tremendous interest for Na-ion batteries (NIBs) due to potentially high volumetric capacity. Yet, the bismuth upon sodiation/desodiation experiencing structure and phase transitions remains unclear, which sets a challenge for ...
Yaxin Huang, Chongyang Zhu, S. Zhang, Xuemin Hu, Kan Zhang, Wenhan Zhou, Shiying Guo, Feng Xu, H. Zeng   +8 more
semanticscholar   +1 more source

Friction Performance of Rubber Sealing Disc Inside Pipe Robots for the Production of High-Paraffin Oil

Lubricants
The in-pipe robot is the most commonly used technique in offshore pipelines. The use of rubber sealing discs is important for in-pipe robots to ensure that the robots are moved by fluid pressures inside offshore pipelines.
Guibin Tan, Ziwei Luo, Yifan Ji, Xing Huang   +3 more
doaj   +1 more source