Results 1 to 10 of about 112,460 (347)

Optimal Perfusion Pressure Enhances Donor Heart Preservation During Normothermic Ex Situ Perfusion in a Rat Transplantation Model [PDF]

Medicina
Background and Objectives: Normothermic ex situ heart preservation maintains donor heart viability by sustaining physiological conditions and reducing ischemic damage. However, the ideal perfusion pressure remains uncertain.
Do Wan Kim, YeongEun Jo, Jiae Seong, Reverien Habimana, Hwa Jin Cho, Mukhammad Kayumov, Inseok Jeong   +6 more
doaj   +3 more sources

Ex situ perfusion fixation for brain banking: a technical report [PDF]

Free Neuropathology, 2022
Perfusion fixation is a well-established technique in animal research to improve preservation quality in the study of many tissues, including the brain.
Andrew McKenzie, Emma Woodoff-Leith, Diana Dangoor, Alessandra Cervera, Hadley Ressler, Kristen Whitney, Kristen Dams-O’Connor, Zhuhao Wu, Elizabeth M.C. Hillman, Alan C. Seifert, John F. Crary   +10 more
doaj   +2 more sources

Long-term ex situ normothermic perfusion of human split livers for more than 1 week

Nature Communications, 2023
Current machine perfusion technology permits livers to be preserved ex situ for short periods to assess viability prior to transplant. Long-term normothermic perfusion of livers is an emerging field with tremendous potential for the assessment, recovery,
Ngee-Soon Lau, Mark Ly, Claude Dennis, Andrew Jacques, Marti Cabanes-Creus, Shamus Toomath, Joanna Huang, Nicole Mestrovic, Paul Yousif, Sumon Chanda, Chuanmin Wang, Leszek Lisowski, Ken Liu, James G. Kench, Geoffrey McCaughan, Michael Crawford, Carlo Pulitano   +16 more
doaj   +2 more sources

Gene therapy during ex situ heart perfusion: a new frontier in cardiac regenerative medicine?

Frontiers in Cardiovascular Medicine, 2023
Ex situ organ preservation by machine perfusion can improve preservation of organs for transplantation. Furthermore, machine perfusion opens up the possibilities for selective immunomodulation, creation of tolerance to ischemia-reperfusion injury and/or ...
Mats T. Vervoorn, Jantijn J. G. J. Amelink, Elisa M. Ballan, Elisa M. Ballan, Elisa M. Ballan, Pieter A. Doevendans, Pieter A. Doevendans, Joost P. G. Sluijter, Joost P. G. Sluijter, Mudit Mishra, Gerard J. J. Boink, Gerard J. J. Boink, Dawn E. Bowles, Niels P. van der Kaaij   +13 more
doaj   +2 more sources

Cytokines Adsorption During Ex Situ Machine Perfusion of Liver Grafts from Elderly Donors: A Pilot, Prospective, Randomized Study [PDF]

Life
Ischemia–reperfusion injury (IRI) is a mechanism based on inflammatory mediators’ release and activation of effectors of damage. Studies showed a correlation between cytokine, severity of damage, and post-operative outcomes. Ex situ perfusion may work as
Giulia Cirillo, Lorenzo Bernardi, Daniele Pezzati, Maria Franzini, Emanuele Balzano, Giovanni Tincani, Jessica Bronzoni, Caterina Martinelli, Arianna Trizzino, Lorenzo Petagna, Paola Carrai, Stefania Petruccelli, Ranka Vukotic, Erlis Uruci, Matilde Masini, Serena Babboni, Serena Del Turco, Riccardo Morganti, Vincenzo De Tata, Aldo Paolicchi, Giandomenico Biancofiore, Adriano Peris, Chiara Lazzeri, Giuseppina Basta, Davide Ghinolfi   +24 more
doaj   +2 more sources

Applying liver transplant techniques in complex liver resection for patients with hilar cholangiocarcinoma: in situ hypothermic portal perfusion without VV bypass [PDF]

World Journal of Surgical Oncology
Background Bismuth–Corlette type IV hilar cholangiocarcinoma (HCCA) with invasion beyond the bifurcation of the anterior and posterior branches of the right portal vein, defined as the P-point, poses a significant challenge for radical resection due to ...
Hongming Xing, Xinyu You, Jianhua Huang, Yu Zhang   +3 more
doaj   +2 more sources

The Landscape of In Situ and Ex Situ Machine Perfusion Utilization for Liver Grafts From Noncardiac Donation After Circulatory Death Donors in the Early era of Machine Perfusion in the United States [PDF]

Transplantation Direct
Background. Donation after circulatory death (DCD) is the major contributor to the growth in deceased organ donation in the United States. Normothermic regional perfusion (NRP) and ex situ machine perfusion (es-MP) have been vital for improving organ ...
Anji Wall, MD, PhD, Jinyu Du, PhD, Matthew Snoddy, MS, Johanna Bayer, MD, Sebastian Danobeitia, MD, PhD, Seung Hee Lee, MD, Eric Martinez, MD, Amar Gupta, MD, Gege Ran, MD, William F Parker, MD, MS, Sumeet Asrani, MD, MSCI, Giuliano Testa, MD, MBA   +11 more
doaj   +2 more sources

Computational fluid dynamic analysis of bioprinted self-supporting perfused tissue models [PDF]

, 2020
Natural tissues are incorporated with vasculature, which is further integrated with a cardiovascular system responsible for driving perfusion of nutrient‐rich oxygenated blood through the vasculature to support cell metabolism within most cell‐dense ...
Bonewald, Lynda F., Ekser, Burcin, Li, Ping, McCarthy, Brian Paul, Prideaux, Matthew, Sego, T. J., Smith, Lester Jeshua, Sterner, Jane, Tovar, Andres   +8 more
core   +1 more source

Absorption and Intestinal Metabolic Profile of Oleocanthal in Rats

Pharmaceutics, 2020
Oleocanthal (OLC), a phenolic compound of extra virgin olive oil (EVOO), has emerged as a potential therapeutic agent against a variety of diseases due to its anti-inflammatory activity.
Anallely López-Yerena, Anna Vallverdú-Queralt, Raf Mols, Patrick Augustijns, Rosa M. Lamuela-Raventós, Elvira Escribano-Ferrer   +5 more
doaj   +1 more source

Ex situ Normothermic Split Liver Machine Perfusion: Protocol for Robust Comparative Controls in Liver Function Assessment Suitable for Evaluation of Novel Therapeutic Interventions in the Pre-clinical Setting

Frontiers in Surgery, 2021
Background:Ex situ donor liver machine perfusion is a promising tool to assess organ viability prior to transplantation and platform to investigate novel therapeutic interventions.
Joseph A. Attard, Joseph A. Attard, Joseph A. Attard, Daniel-Clement Osei-Bordom, Daniel-Clement Osei-Bordom, Yuri Boteon, Yuri Boteon, Yuri Boteon, Lorraine Wallace, Lorraine Wallace, Vincenzo Ronca, Vincenzo Ronca, Gary Reynolds, Gary Reynolds, M. T. P. R. Perera, Ye Htun Oo, Ye Htun Oo, Ye Htun Oo, Ye Htun Oo, Hynek Mergental, Hynek Mergental, Hynek Mergental, Darius F. Mirza, Simon C. Afford, Simon C. Afford   +24 more
doaj   +1 more source