Results 281 to 290 of about 112,460 (347)

In situ lung perfusion with cisplatin an experimental study

Cancer, 1993
This research work was planned to evaluate the soundness of in situ lung perfusion as a regional administration modality of chemotherapeutic agents.Sixteen pigs were randomly divided into four groups and received cisplatin (2.5 mg/kg) through the pulmonary artery using one of the following techniques: stop-flow (Group 1); stop-flow/out-flow occlusion ...
Ratto GB, Esposito M, Leprini A, Civalleri D, DE CIAN, FRANCO, Vannozzi MO, Romano P, Canepa M, Zaccheo D.   +8 more
openaire   +3 more sources

Moderate-Flow Perfusion is Superior to Low-Flow Perfusion in Ex Situ Lung Perfusion

Transplantation Proceedings
Full-flow perfusion during prolonged ex situ lung perfusion (ESLP) results in unacceptable pulmonary edema formation. Clinical ESLP at 30% to 50% predicted cardiac output (CO) supports acceptable physiologic outcomes; however, progressive pulmonary edema still develops.
Keir Forgie, Nicholas Fialka, Abeline Watkins, Katie Du, Sayed Himmat, Sanaz Hatami, Mubashir Khan, Xiuhua Wang, Ryan Edgar, Katie-Marie Buswell-Zuk, Darren Freed, Jayan Nagendran   +11 more
openaire   +2 more sources

Influence of perfusate composition on drug disposition in the in-situ perfused rat lung

International Journal of Pharmaceutics, 2009
This study compared the impact of two perfusates (A: 4.5% BSA-MOPS buffer and B: 4% dextran and 0.5% BSA-MOPS buffer) on the pharmacokinetics of the physiological markers [(3)H]-water, [(14)C]-sucrose, [(14)C]-antipyrine and Evans Blue-labelled albumin; and the drugs atenolol and propranolol using an in-situ single pass perfusion model in the rat lung.
Liu, X., Wang, J. Y., Khlentzos, A. M., Fontaine, F., Nikolovski, J., Goh, L.- A., Roberts, M. S.   +6 more
openaire   +4 more sources

Kidney: microperfusion--double-perfused tubule in situ.

Methods in enzymology, 1990
Publisher Summary: This chapter discusses that the intact mammalian kidney double perfusion is possible only by applying micropuncture techniques. It is obvious that by double perfusion, a three compartment (lumen-cell-interstitium) approach is applicable to the tubules in situ: Either in steady state or after rapid solution changes the concentrations ...
Ullrich, K., Rumrich, G.
openaire   +2 more sources

Sequential Normothermic Regional Perfusion and End-ischemic Ex Situ Machine Perfusion Allow the Safe Use of Very Old DCD Donors in Liver Transplantation

Transplantation
Background. In Italy, 20 min of continuous, flat-line electrocardiogram are required for death declaration. Despite prolonged warm ischemia time, Italian centers reported good outcomes in controlled donation after circulatory death (cDCD) liver ...
F. Torri, E. Balzano, Fabio Melandro, P. Maremmani, P. Bertini, Paolo Lo Pane, M. Masini, M. I. Rotondo, S. Babboni, S. Del Turco, Stefano Antonelli, V. De Tata, G. Biancofiore, F. Guarracino, Aldo Paolicchi, Paolo De Simone, G. Basta, D. Ghinolfi   +17 more
semanticscholar   +1 more source

In situ isolated perfused and innervated left hemidiaphragm preparation

Journal of Applied Physiology, 1989
We developed a vascularly isolated in situ preparation of the left hemidiaphragm in which arterial blood was only provided through the left phrenic artery and the venous blood only drained through the phrenic vein. The costal margins were secured and connected to three force transducers. Muscle shortening was measured by sonomicrometry.
S N, Hussain, C, Roussos, S, Magder
openaire   +2 more sources

Vascular responsiveness of the in situ perfused dog pancreas

European Journal of Pharmacology, 1974
Abstract The in situ perfused dog pancreas was utilized to investigate: (a) the contribution of humoral vasoactive agents which are released in shock to maintain the development of pancreatic hypoperfusion, (b) the effectiveness of glucocorticoids as splanchnic vasodilator agents as a possible mechanism of thier beneficial effect in shock, and (c ...
R J, Gorczynski, J A, Spath, A M, Lefer
openaire   +2 more sources

In Situ Perfusion System for Oral Mucosal Absorption in Dogs

Journal of Pharmaceutical Sciences, 1990
To evaluate oral mucosal absorption of drugs in dogs, a newly designed in situ perfusion system with a circulating perfusion chamber was developed. The utility of the perfusion system was investigated by using three drugs: salicylic acid (SA), sulfadimethoxine (SM), and diltiazem (DIL).
H, Yamahara, T, Suzuki, M, Mizobe, K, Noda, M, Samejima   +4 more
openaire   +2 more sources

Experimental Applications of in situ Liver Perfusion Machinery for the Study of Liver Disease

Molecules and Cells, 2018
The liver is involved in a wide range of activities in vertebrates and some other animals, including metabolism, protein synthesis, detoxification, and the immune system. Until now, various methods have been devised to study liver diseases; however, each
Won-Mook Choi, H. Eun, Young-Sun Lee, Sun Jun Kim, Myung-Ho Kim, Jun‐Hee Lee, Young-Ri Shim, Hee-Hoon Kim, Y. Kim, Hyon-Seung Yi, W. Jeong   +10 more
semanticscholar   +1 more source

Ex situ machine perfusion in kidney transplantation

Artificial Organs, 2021
Sarah Bouari, Elsaline Rijkse, Sarah A. Hosgood, Robert C. Minnee   +3 more
openaire   +2 more sources