Results 241 to 250 of about 7,982,325 (356)

Generation of Advanced Blood–Brain Barrier Spheroids Using Human‐Induced Pluripotent Stem Cell‐Derived Brain Capillary Endothelial‐Like Cells

open access: yesAdvanced Biology, EarlyView.
In this article, the establishment and characterization of a self‐assembled 3D BBB spheroid model using human induced pluripotent stem cell (hiPSC)‐derived and primary cells is reported. Spheroids demonstrate in‐vivo like tight junction ultrastructure and, in comparison to 2D mono‐cultures, higher transcript expression of BBB specific genes.
Sanjana Mathew‐Schmitt   +10 more
wiley   +1 more source

Considering the Risks and Costs of Solid Organ Xenotransplantation

open access: yesAdvanced Biology, EarlyView.
This perspective discusses the rationale, risks, and costs of whole‐organ xenotransplantation. It considers alternative strategies to obviate the demand for transplants and optimize allotransplantation systems and practices that do not impose xenotransplantation's harms and risks, and whether they are the most ethical and effective means to increase ...
Catharine E. Krebs   +5 more
wiley   +1 more source

Adaptive evolution of <i>Candida albicans</i> through modulating TOR signaling. [PDF]

open access: yesmBio
Zhang Y   +8 more
europepmc   +1 more source

Preventive Effect of Metformin in Radiation‐Induced Xerostomia

open access: yesAdvanced Biology, EarlyView.
Head and neck cancer patients who received radiotherapy complain of severe dry mouth due to damage to the salivary glands. Metformin is an antidiabetic drug, but its radio‐protective effect has been reported. It is confirmed that metformin protects the salivary glands from radiation and provides evidence for the use of metformin in cancer treatment in ...
Sungryeal Kim   +5 more
wiley   +1 more source

Depletion of TP53 in Human Pluripotent Stem Cells Triggers Malignant‐Like Behavior

open access: yesAdvanced Biology, EarlyView.
Human pluripotent stem cells (hPSCs) with TP53‐depleting mutations are generated, mimicking commonly occurring events in vitro. Loss of TP53 does not alter pluripotency status or in vitro differentiation potential but causes genetic instability and transcriptome changes and confers superior clonal and anchorage‐free growth and higher chemotherapeutic ...
Joaquin Montilla‐Rojo   +9 more
wiley   +1 more source

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