Results 101 to 110 of about 590,741 (312)

Applying the adverse outcome pathway (AOP) for food sensitization to support in vitro testing strategies [PDF]

, 2019
Background Before introducing proteins from new or alternative dietary sources into the market, a compressive risk assessment including food allergic sensitization should be carried out in order to ensure their safety.
Benedé, Sara, Bouchaud, Grégory, Costa, Ana, Denery-Papini, Sandra, Díaz-Perales, Araceli, E.M. Willemsen, Linette, Garrido-Arandia, María, Gavrovic-Jankulovic, Marija, H.M. van Bilsen, Jolanda, Hayen, Simone, L. Bavaro, Simona, L. Roggen, Erwin, Lozano-Ojalvo, Daniel, M. Antunes, Célia, Wróblewska, Mónica   +14 more
core   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Anthelmintic action of plant cysteine proteinases against the rodent stomach nematode, Protospirura muricola, in vitro and in vivo [PDF]

, 2007
Cysteine proteinases from the fruit and latex of plants, including papaya, pineapple and fig, were previously shown to have a rapid detrimental effect, in vitro, against the rodent gastrointestinal nematodes, H eligmosomoides polygyrus (which is found in
Behnke, J.M., Buttle, D.J., Duce, I.R., Lowe, A.E., Stepek, G.   +4 more
core   +3 more sources

Immunological behavior of in vitro digested egg‐white lysozyme

Molecular Nutrition & Food Research, 2013
ScopeBesides its antimicrobial properties, lysozyme (LYS) is one of the major allergens from hen egg. This paper addresses the identification of the peptides produced upon in vitro gastrointestinal digestion of LYS, together with their IgE‐binding and biological activity as a contribution to the understanding of what makes it a relevant allergen ...
Jiménez Saiz, Rodrigo, Benedé, Sara, Miralles, Beatriz, López-Expósito, Iván, Molina, Elena, López-Fandiño, Rosina   +5 more
openaire   +3 more sources

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Effect of pH and level of concentrate in the diet on the production of biohydrogenation intermediates in a dual-flow continuous culture [PDF]

, 2009
Milk fat depression in cows fed high-grain diets has been related to an increase in the concentration of trans-10 C-18:1 and trans-10, cis-12 conjugated linoleic acid (CLA) in milk.
Calsamiglia, S, Cardozo, PW, Fuentes, MC, Vlaeminck, Bruno   +3 more
core   +2 more sources

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Effect of processing methods on mineral bioaccessibility in common beans

Scientific Reports
Mineral bioaccessibility is a concern in legume based foods and can be enhanced using different techniques. This study aimed to evaluate the effects of processing conditions on the in vitro mineral bioaccessibility of small black common beans cultivated ...
Wabi Bajo, Borges Chambal, Custodia Macuamule   +2 more
doaj   +1 more source

Comparison of 2-pool and 3-pool digestion kinetic model predictions of neutral detergent fiber digestibility of forages from commercially available data

Journal of Dairy Science
: Sizes and rates of potentially digestible (B) and undegradable (C) pools of amylase-treated neutral detergent fiber (aNDF) are used to predict ruminal aNDF digestibility (raNDFD%) in widely used dairy cattle diet formulation programs.
M.C. Barry, M.B. Hall
doaj   +1 more source