Results 211 to 220 of about 336,569 (265)

B4GALNT4‐Mediated Glycosylation of PDK1 Activates the PI3K‐AKT Signaling Pathway to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
This study identifies B4GALNT4 as a key driver of prostate cancer (PCa). It shows that B4GALNT4 glycosylates PDK1 protein at the N531 site, which stabilizes the PDK1 and constitutively activates the PI3K‐AKT pathway. This mechanism promotes tumor cell proliferation, migration, and invasion. The findings establish the B4GALNT4‐PDK1 glycosylation axis as
Shaoqin Jiang, Mengqiang Li, Qingfu Su, Ruiling Dou, Shaoshan Lin, Jili Zhang, Xiaochen Sun, Haolan Yu, Wei Bao, Min Qu, Yan Wang, Chenghua Yang, Xu Gao   +12 more
wiley   +1 more source

Multifilm Mass Transfer and Reaction Rate Kinetics in a Newly Developed In Vitro Digestion System for Carbohydrate Digestion. [PDF]

Foods
Sun Y, Cheng J, Cheng S, Langrish TAG.
europepmc   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

The Effect of Multilayer Nanoemulsion on the In Vitro Digestion and Antioxidant Activity of β-Carotene. [PDF]

Antioxidants (Basel)
Sun MZ, Kim DY, Baek Y, Lee HG.
europepmc   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Comparison of three different in vitro digestion methods for carbohydrates. [PDF]

J Food Sci Technol
Xiao Y, Li S, Li J, Bi Y, Xu X, Zhang H.
europepmc   +1 more source

Effect of dietary carnosine during in vitro digestion of a burger meal combo model including ascorbic acid as an antioxidant and fructose as a pro-oxidant. [PDF]

J Food Sci
Li YY, Yaylayan V, Palin MF, Ngapo TM, Cliche S, Gagnon F, Gariépy C.   +6 more
europepmc   +1 more source

Investigation of the physicochemical factors affecting the in vitro digestion and glycemic indices of indigenous indica rice cultivars. [PDF]

Sci Rep
Govindaraju I, Das AR, Chakraborty I, Mal SS, Sarmah B, Baruah VJ, Mazumder N.   +6 more
europepmc   +1 more source

Beef- and Pork-Based Dishes from Catering Services: Composition and In Vitro Digestion Effects on Digestibility and Lipid Oxidation. [PDF]

Foods
Ariz-Hernandez I, Schulz P, Garayoa R, Ansorena D, Astiasaran I.   +4 more
europepmc   +1 more source

Bioaccessibility and Biological Activities of Phytochemicals from Wild Plant Infusions and Decoctions Before and After Simulated In Vitro Digestion. [PDF]

Plant Foods Hum Nutr
Monari S, Ferri M, Zappi A, Escórcio R, Correia VG, Cairrão A, Bento A, Pereira CS, Tassoni A.   +8 more
europepmc   +1 more source