Design and Synthesis of Peptide‐Polyester Conjugates for Cell‐Mediated Scaffold Degradation
Advanced Healthcare Materials, EarlyView.This work describes polycaprolactone (PCL)‐based biomaterials engineered to degrade in response to cell‐secreted proteases. A fast‐degrading peptide (Fast) sequence is integrated into a PCL conjugate backbone to produce a biomaterial that is selectively degraded by multiple cell types compared to its scrambled control (ScrFast).
Korina Vida G. Sinad +7 more
wiley +1 more source
Luminal Fluid Motion Inside an In Vitro Dissolution Model of the Human Ascending Colon Assessed Using Magnetic Resonance Imaging. [PDF]
Pharmaceutics, 2021 O'Farrell C +6 more
europepmc +1 more source
Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy
Advanced Healthcare Materials, EarlyView.Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima +15 more
wiley +1 more source
The correlation of in vitro dissolution and in vivo absorption
, 2016 학위논문(석사)--아주대학교 일반대학원 :약학,2016. 21. Introduction 1 2. Materials and methods 10 2.1. Materials & instruments 10 2.2. Preparation of simulated dissolution media 11 2.3. In vitro simulation dissolution method 13 2.4.
Kim Jae Seon
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An In Vitro Model for Release of Acetaminophen When an Overdose is Ingested Orally
1424Acetaminophen (paracetamol) is an analgesic and antipyretic drug that is widely used across the globe due to its efficacy and safety within the therapeutic dose range.
Chronowska, Maja, Dressman, Jennifer Joy
core +1 more source
Amorphous Solid Dispersions and the Contribution of Nanoparticles to In Vitro Dissolution and In Vivo Testing: Niclosamide as a Case Study. [PDF]
Pharmaceutics, 2021 Jara MO, Warnken ZN, Williams RO.
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez +6 more
wiley +1 more source
Benznidazole in vitro dissolution release from a pH-sensitive drug delivery system using Zif-8 as a carrier. [PDF]
J Mater Sci Mater Med, 2021 de Moura Ferraz LR +7 more
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.A human 3D bone niche integrating osteoblasts and osteoclasts enables co‐culture with prostate cancer cell lines and patient‐derived organoids. The engineered niche (i) models aspects of reciprocal phenotypic regulation between osteoblasts and cancer cells, (ii) captures osteoclast‐enhanced osteomimicry in tumor cells, and (iii) establishes a ...
Andrea Mazzoleni +7 more
wiley +1 more source
Modeling and Comparison of Dissolution Profiles of Diltiazem Modified-Release Formulations
, 2009 Generic drugs offer a cost-effective alternative to brand-name products. However, the main concern with modified-release formulations is the substitution of one product for another.
D. Samaha, R. Shehayeb, S. Kyriacos
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