A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Reproduction in selected New Zealand native ferns and their suitability for revegetation : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Science in Plant Biology at Massey University, Palmerston North, New Zealand [PDF]
, 2006 The potential to use New Zealand native ferns for revegetation was assessed in laboratory , nursery and field experiments. Laboratory experiments indicated that the three native fern species. Blechnum novae-zelandiae.
Denton-Giles, Matthew
core
The Effect of 2, 4 D (Dichlorophenoxyacetic acid) and BAP (Benzyl Amino Purine) Concentration on the Establishment of Patchouli (Pogostemon cablin Benth) in Vitro [PDF]
, 2019 Dwika Karima Wardani +2 more
openalex +1 more source
Establishment of a Transformation Coupled in vitro End Joining Assay to Estimate Radiosensitivity in Tumor Cells [PDF]
, 2020 Sarah Degenhardt +8 more
openalex +1 more source
Establishment of an In Vitro Model to Study Viral Infections of the Fish Intestinal Epithelium [PDF]
, 2023 Guro Løkka +3 more
openalex +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Revegetation Research on Coal Mine Overburden Materials in Interior to Southcentral Alaska [PDF]
, 1987 This report was reprinted from Focus on Alaska's Coal '86: Proceedings of the Conference MIRL Report Number 72. The pagination in the original publication has been retained.
Mitchell, Wm. W.
core
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
In vitro establishment of Phalaenopsis
Biotecnología Vegetal, 2007 The present work had as objectives to establish in vitro axillary buds of the floral stalk and to germinate in vitro botanical seeds of Phalaenopsis to obtain the formation of protocorm like bodies. As vegetable material axillary buds of the floral stalk
Manuel de Feria +2 more
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