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Establishment of in-vitro models of chemotherapy resistance

Anti-Cancer Drugs, 2007
Chemotherapy resistance is one of the most prevalent obstacles to the treatment of cancer, resulting in increased mortality and prolonged exposure to cytotoxic agents with no treatment benefit. One of the tools utilized in the study of mechanisms of chemotherapy resistance are established cell lines derived from human neoplasms. These cell lines can be
Mark B, Watson   +2 more
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Establishing Liver Bioreactors for In Vitro Research

2014
In vitro systems that can effectively model liver function for long periods of time are fundamental tools for preclinical research. Nevertheless, the adoption of in vitro research tools at the earliest stages of drug development has been hampered by the lack of culture systems that offer the robustness, scalability, and flexibility necessary to meet ...
Sofia P, Rebelo   +4 more
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Establishment of a naphthalene cataract model in vitro

Experimental Eye Research, 1992
In the past, almost all studies on naphthalene cataract were based on in vivo experiments. Such studies are laborious and time-consuming and are complicated by systemic toxicity arising from the metabolites of naphthalene. In order to study the direct effects of naphthalene metabolites on the lens, we established an in vitro 'naphthalene cataract ...
G T, Xu, J S, Zigler, M F, Lou
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Establishing an In Vitro Fertilization Program

Hospital Practice, 1984
As in vitro fertilization becomes more acceptable, it will become a standard procedure in any obstetrics-gynecology service that seeks to offer a full range of tertiary care. Experience with development and operation of such a service is described in detail, as is the procedure itself—from oocyte extraction, fertilization, and transfer of the embryo to
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Established Eurythermic Line of Fish Cells in vitro

Science, 1962
An established line of fish cells has been propagated in vitro for 21 months and 48 subcultivations. Important characteristics of the cells are described.
K, WOLF, M C, QUIMBY
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Perspectives of in vitro dissolution tests in establishing in vivo/in vitro correlations

European Journal of Drug Metabolism and Pharmacokinetics, 1993
Perspectives of in vitro dissolution tests in establishing an in vivo/in vitro correlation are considered at three different levels. The first involves the selection of a drug product, or suitable batch(es), for the correlation study. This requires evaluation of the biopharmaceutical properties of the proposed drug from a profile compiled from a set of
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The Establishment of Human Choriocarcinoma Cell Line in Vitro

Asia-Oceania Journal of Obstetrics and Gynaecology, 1983
AbstractA new tissue culture cell line, designated NUC‐1, has been established from human choriocarcinoma of the uterus. The cell line has now been growing in vitro for 28 months and has been subcultured 32 times. The cell grew in a monolayer sheet, showed a marked tendency to pile up, and released human chorionic gonadotropin (hCG) in media.
K, Suzumori   +4 more
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Establishment of an Embryo Implantation Model In Vitro

Journal of Visualized Experiments
Embryo implantation is the first step in the establishment of a successful pregnancy. An in vitro model for embryo implantation is critical for basic biological research, drug development, and screening. This paper presents a simple, rapid, and highly efficient in vitro model for embryo implantation.
Xuemei, Wang   +3 more
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In vitro characteristics of two established hepatoma cell lines

Experimentelle Pathologie, 1978
The in vitro behaviours of a fibroblast-like (DENA-RH 13) and an epithelial-like (DENA-RH 13A) cell line, derived from a chemically induced hepatocarcinoma of rat are described. The DENA-RH 13A can be maintained and studied either in monolayer as a transplantable solid tumor or in fluid-suspension culture as ascites tumor in Wistar rats.
G, Neupert, T, Sterba
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