Results 91 to 100 of about 47,761 (377)

5’‐Methylthioadenosine Metabolic Reprogramming Drives H3K79 Monomethylation‐Mediated PAK2 Upregulation to Promote Cadmium‐Induced Breast Cancer Progression by Impairing Autophagic Flux

Advanced Science, EarlyView.
Cadmium, a carcinogenic heavy metal, drives breast cancer progression via metabolic reprogramming and autophagic flux disruption. Multi‐omics revealed cadmium‐induced 5'‐methylthioadenosine depletion activates DOT1L‐mediated H3K79me1 at PAK2 promoter, upregulating PAK2 to block autophagy and driving malignancy. Clinically, 5'‐methylthioadenosine levels
Jingdian Li, Ping Deng, Tengfei Fan, Yuchen Qu, Miduo Tan, Yidan Liang, Peng Gao, Yongchun Peng, Mingke Qin, Sheng Jie, Rongrong Hao, Liting Wang, Lei Zhang, Chunhai Chen, Mindi He, Qinlong Ma, Yan Luo, Li Tian, Jia Xie, Mengyan Chen, Rui Tian, Min Li, Zhengping Yu, Zhou Zhou, Huifeng Pi   +24 more
wiley   +1 more source

Dysfunctional Decidual CD4+T Cells Induce Recurrent Pregnancy Loss via Palmitoylation‐Dependent Tim‐3 Lysosomal Sorting and Degradation

Advanced Science, EarlyView.
Dysfunctional decidual CD4+T cells induce recurrent pregnancy loss via palmitoylation‐dependent Tim‐3 lysosomal sorting and degradation. The integrated bioinformatics, proteomic, functional and model studies elucidate that Tim‐3 is palmitoylated by ZDHHC3 at Cys9. Sortilin bound to and directed palmitoylated Tim‐3 toward lysosome degradation, resulting
Liyuan Cui, Xinhang Meng, Yujie Luo, Jinfeng Qian, Fengrun Sun, Mingke Qiu, Songcun Wang   +6 more
wiley   +1 more source

Predicting live birth, preterm and low birth weight infant after in-vitro fertilisation: a prospective study of 144018 treatment cycles [PDF]

, 2011
Background The extent to which baseline couple characteristics affect the probability of live birth and adverse perinatal outcomes after assisted conception is unknown.
A Nyboe Andersen, A Nyboe Andersen, A Templeton, AM Stolwijk, AM Stolwijk, CC Hunault, CC Hunault, CW Redman, D Bodri, Debbie A. Lawlor, DO Mook-Kanamori, E Leushuis, E Villamor, E von Elm, ER DeLong, ES Draper, G Palermo, GA Colditz, GC Smith, I Craft, JJ Morrison, JK Min, JL Evers, JMJ Smeenk, KG Nygren, LB Romundstad, M Cooley, MJ Pencina, N Johnson, Nicholas M. Fisk, O Basso, P Stutchfield, R Bukowski, RA Jackson, RJ Paulson, Scott M. Nelson, VM Allen, YT van der Schouw   +37 more
core   +4 more sources

Effect of lifestyle or metformin interventions before IVF/ICSI treatment on infertile women with overweight/obese and insulin resistance: a factorial design randomised controlled pilot trial

Pilot and Feasibility Studies, 2023
Background For infertile women with overweight/obesity and insulin resistance (IR), it is uncertain whether intervention before infertility treatment can improve live birth rate (LBR).
Xiaojuan Wang, Sufen Cai, Sha Tang, Lanlin Yang, Jing Tan, Xin Sun, Fei Gong   +6 more
doaj   +1 more source

A Novel Cultivation System for Germ Cell Proliferation and Sustaining Whole Testicular Niche

Advanced Science, EarlyView.
A hydrogel microneedle‐based system enables whole testicular cultivation, supporting spermatogonial proliferation and enhancing spermatogenesis in vitro. This ‘whole testicular spermatogonia pool’ (WTSP) significantly increases spermatid production and fertility potential in mice. This system also promotes spermatogonial expansion in human fetal testes,
Yu Xia, Xiaoxuan Zhang, Bohang Zhang, Minhui Lu, Qing Cheng, Li Liu, Lifang Shi, Yiqiang Cui, Dingdong Chen, Laihua Li, Xuejiang Guo, Jingtao Guo, Jiahao Sha, Yuanjin Zhao, Yan Yuan   +14 more
wiley   +1 more source

Assisted conception and Embryo Research with reference to the tenets of Catholic Christianity [PDF]

, 2017
Religion has a considerable influence over the public’s attitudes towards science and technologies. The objective of the paper is to understand the ethical and religious problems concerning the use of embryo for research in assisting conception for ...
Mitra, Piyali
core  

Clinical prediction models to inform individualized decision-making in subfertile couples : a stratified medicine approach [PDF]

, 2014
Funding This work was supported by a Chief Scientist Office Postdoctoral Training Fellowship in Health Services Research and Health of the Public Research (Ref PDF/12/06).
Bhattacharya, S., McLernon, D.J., Mol, B.W.J., Steyerberg, E.W., te Velde, E.R.   +4 more
core   +3 more sources

Ruptured Tubal Triplet Heterotopic Pregnancy After in Vitro Fertilisation: A Case Report

Gynecology Obstetrics & Reproductive Medicine, 2011
To analyse the incidence, diagnostic and therapeutic management of heterotopic pregnancy following in vitro fertilisation (IVF). We present a case who had a ruptured left tubal heterotopic triplet pregnancy at nine weeks of gestation following in vitro ...
Mehmet Osmanağaoğlu, Murat Aksoy, Ceylan İlhan, Recep Erin   +3 more
doaj  

Cationic Peptoids for Systemic In Vivo Cartilage‐Targeting

Advanced Science, EarlyView.
Systemically‐dosed Cy5‐labeled cationic peptoid probe (NlysO)7 (yellow) binds to the cartilage's glycosaminoglycan content in vivo across the entire body of a neonatal mouse imaged by light sheet fluorescence microscopy, revealing fluorescence uptake in generic cartilage as well as the developing and ossifying bones.
Chaonan Zhang, Rongmao Qiu, Yongjie Huang, Yinghua Liu, Kui Huang, Suwen Zhao, Yang Li   +6 more
wiley   +1 more source

Intracytoplasmic sperm injection (ICSI) versus conventional in vitro fertilisation (IVF) in couples with non-severe male infertility (NSMI-ICSI): protocol for a multicentre randomised controlled trial

BMJ Open, 2019
Introduction Intracytoplasmic sperm injection (ICSI), originally introduced as add-on to in vitro fertilisation (IVF) for couples with severe male infertility, is in current clinical practice also used in couples with mild male or even unexplained ...
D. Zheng, L. Zeng, R. Yang, Y. Lian, Yi-Min Zhu, Xiao-yan Liang, Li Tang, Huichun Wang, Yunxia Cao, G. Hao, Jianqiao Liu, Junli Zhao, Rui Wang, B. Mol, Rong Li, He-feng Huang, J. Qiao   +16 more
semanticscholar   +1 more source