Results 121 to 130 of about 47,761 (377)

Tead1a Initiates Transcriptional Priming Through the TEAD1a/YAP‐Notch1‐Spi1/Cebpα Axis to Promote Neutrophil Fate

Advanced Science, EarlyView.
This study discovered that the protein TEAD1a is crucial for neutrophil development. In zebrafish models, disrupting TEAD1a or its interaction with partner protein YAP1 caused severe neutrophil deficiency. TEAD1a functions during the early HSC stage, activates Notch1 signaling in the GMP stage, and triggers Spi1 and Cebpα to drive neutrophil terminal ...
Wang Yiqin, Yang Ruimeng, Wang Peihong, Liu Xiaohui, Yuan Hao, Huang Hongli, Zhou Yongjian, Xie Baoshu   +7 more
wiley   +1 more source

The impact of female obesity on the outcome of fertility treatment [PDF]

, 2010
Peer reviewedPublisher ...
Abha Maheshwari, Ayyad, Balen, Balen, Bellver, Bellver, Bellver, Bergh, Brannian, Clark, Diamanti-Kandarakis, Dodson, Ehrmann, Gil-Campos, Hamilton-Fairley, Hollmann, Hossain, Huber-Buchholz, Imani, Imani, Jungheim, Kiddy, Koloszar, Law, Li, Maheshwari, Metwally, Metwally, Metwally, Moran, Moschos, Mulders, Nohr, Ogden, Orvieto, Palomba, Panidis, Pasquali, Prentice, Rich-Edwards, Shilpi Pandey, Siladitya Bhattacharya, Suruchi Pandey, Tang, The, Tsagareli, Van, Wadden, Wang, Wattanakumtornkul, Wise, Zaadstra, Zachariah, Zhang   +53 more
core   +3 more sources

Fibroids and Infertility

European Medical Journal Reproductive Health, 2019
Infertility is generally defined as the failure to conceive after ≥1 year of unprotected sexual intercourse. Because infertility tends to be multicausal, fibroids (as the sole identified factor for infertility) were only identified in about 2.4% of ...
Essam El Mahdi
doaj  

Lentiviral vector transduction of spermatozoa as a tool for the study of early development

FEBS Open Bio, 2014
Spermatozoa and lentiviruses are two of nature’s most efficient gene delivery vehicles. Both can be genetically modified and used independently for the generation of transgenic animals or gene transfer/therapy of inherited disorders.
Anil Chandrashekran, Ihsan Isa, Jayesh Dudhia, Adrian J. Thrasher, Nicholas Dibb, Colin Casimir, Carol Readhead, Robert Winston   +7 more
doaj   +1 more source

The Critical Role of Enhanced OXPHOS and Mitochondrial Hyperpolarization in Simulated Microgravity‐Induced Oocyte Maturation Arrest

Advanced Science, EarlyView.
Simulated microgravity induces distinct mitochondrial hyperactivation patterns‐elevated OXPHOS and MMP‐which accelerate meiosis without SAC failure but delays MTOC coalescence, leading to spindle defects and meiotic arrest. Prolonging M‐phase restores MTOC assembly and oocyte maturation.
Lei Ge, Yuqing Gao, Feifei Du, Chiyuan Ma, Tianxia Xiao, Yali Yang, Xiaohua Lei, Jian V. Zhang   +7 more
wiley   +1 more source

EETs Reduction Contributes to Granulosa Cell Senescence and Endometriosis‐Associated Infertility via the PI3K/AKT/mTOR Signaling Pathway

Advanced Science, EarlyView.
1) 14, 15‐EET levels were decreased in ovarian granulosa cells, follicular fluid, peritoneal fluid from endometriosis patients. 2) EETs reduction in endometriosis follicular fluid aggravated granulosa cell senescence. 3) ROS reduced 14, 15‐EET levels by upregulating EPHX2 through a mechanism involving histone methylation modification.
Xiang Lin, Weijia Gu, Xiaomei Tong, Mengru Lai, Yi Zhang, Na Liu, Xiaoying Jin, Chao Li, Dong Huang, Feng Zhou, Yongdong Dai, Songying Zhang   +11 more
wiley   +1 more source

Inhibition of AMPKα Pathway by Podocyte GOLM1 Exacerbates Diabetic Nephrology in Mice

Advanced Science, EarlyView.
Podocyte Golgi membrane protein 1 interacts with epidermal growth factor receptor to inhibit peroxisome proliferator activated receptor γ, and then inactivates adenosine monophosphate activated protein kinase α pathway, which facilitates diabetes‐related inflammation, oxidative damage, apoptosis, and renal dysfunction.
Peng Xu, Kaiqiang Li, Huasong Liu, Aibo Xu, Zhewei Zhang, Yimin Yang, Xiaobo Lai, Ke Hao, Kui Fang, Zeyu Lai, Xiping Ou, Yuqun Cai, Zhen Wang, Keda Lu, Wanli Jiang   +14 more
wiley   +1 more source

Fertilisation in vitro. [PDF]

, 1979
Mr Steptoe, R. G. Edwards
openalex   +1 more source

In vitro fertilisation for all?

BMJ, 2003
The question is for local purchasers to answer, not for NICE The National Institute for Clinical Excellence (NICE) was established in 1999 to provide authoritative advice to the NHS on the clinical and cost effectiveness of medical technologies, to devise and approve guidelines for the use of such technologies, and to contribute to improvement of ...
openaire   +3 more sources

Endometriosis and in vitro fertilisation.

Experimental and therapeutic medicine, 2018
The aim of the present review was to discuss a matter of concern in the clinical field of obstetrics/gynecology, namely the potency of in vitro fertilization (IVF) in the management of endometriosis-associated infertility. Endometriosis is a medical condition affecting one tenth of women in their fertile years, and accounts for up to 50% of infertile ...
Vassilopoulou, Loukia, Matalliotakis, Michail, Zervou, Maria I., Matalliotaki, Charoula, Spandidos, Demetrios A., Matalliotakis, Ioannis, Goulielmos, George N.   +6 more
openaire   +2 more sources