Results 211 to 220 of about 108,618 (264)

Multiomics analyses reveal that PRMT5 regulates membrane transport and cholesterol synthesis in white adipocytes

open access: yesiMetaOmics, EarlyView.
Prmt5AKO downregulates genes related to fatty acid transport and triacylglycerol synthesis, while upregulating genes involved in glucose transport and cholesterol biogenesis. These changes cause alternation in lipid composition and metabolic phenotypes of Prmt5AKO mice. Abstract The adipose tissue (AT) is a main regulator of systemic energy homeostasis,
Xiyue Chen   +7 more
wiley   +1 more source

Genome‐wide CRISPR screen reveals an uncharacterized spliceosome regulator as new candidate immunotherapy target

open access: yesiMeta, EarlyView.
This study identifies the uncharacterized gene C9ORF50 as a novel regulator of immune evasion. Functioning as an intrinsically disordered protein, C9ORF50 drives liquid‐liquid phase separation to facilitate spliceosome assembly and maintain RNA splicing fidelity.
Tong Shao   +24 more
wiley   +1 more source

Use and User Experience of a Preconception Lifestyle App for Couples Undergoing in Vitro Fertilization: Mixed Methods Study.

open access: yesJMIR Hum Factors
Boedt T   +7 more
europepmc   +1 more source

Salt‐induced nutritional and metabolic shifts in halophytes: implications for food security

open access: yesJournal of the Science of Food and Agriculture, EarlyView.
Abstract Plant species vary in their response to salinity: some crops show a degree of salt tolerance, while halophytes – whether wild or cultivated – are characterized by a high capacity to thrive under saline conditions. Halophytes are considered a source of valuable secondary metabolites with potential economic value, yet they might also produce ...
Giulia Atzori   +9 more
wiley   +1 more source

Effect of beneficial microbes applications on nutritional profiles of organic tomatoes revealed by LC‐MS‐qTOF metabolomics

open access: yesJournal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND The use of microorganisms and biostimulants is increasingly supported in agriculture because of their advantageous impact on plant disease management, growth enhancement and the synthesis of beneficial bioactive secondary metabolites (SMs). Tomato (Solanum lycopersicum) is an important crop and is consumed worldwide because it is an
Daria Lotito   +8 more
wiley   +1 more source

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