Results 71 to 80 of about 108,618 (264)

Depletion of Sorcs3 Activates Totipotency in Mouse Embryonic Stem Cells by Modulating Key Signaling Pathways

open access: yesAdvanced Science, EarlyView.
In this article, Shuai and colleagues found that depletion of Sorcs3 could activate totipotency in mESCs, promising bidirectional differentiation potential to embryonic and extraembryonic lineages. The underlying mechanism might be activation of Tfap2c and repression of TGF‐β, PI3K‐AKT, and lysosome pathways.
Wenhao Zhang   +12 more
wiley   +1 more source

5‐Hydroxymethylcytosine Dynamics Reveals Coordinated Reprogramming of Parental Genomes and X Chromosome Dosage Balance in Mouse SCNT Embryos

open access: yesAdvanced Science, EarlyView.
Genome‐wide, high‐resolution profiling of hydroxymethylation in mouse SCNT embryos reveals a transient, allele‐symmetric 5hmC reprogramming pattern distinct from natural embryos, with X‐chromosomes and imprinting control regions resistant to proper remodeling.
Zeming Xiang   +9 more
wiley   +1 more source

Evaluation of prooxidant-antioxidant balance in in vitro fertilization-conceived mice [PDF]

open access: diamond, 2018
Hamid Ahmadi   +4 more
openalex   +1 more source

Inactivated COVID-19 Vaccination Did Not Affect in Vitro Fertilization (IVF) / Intra-Cytoplasmic Sperm Injection (ICSI) Cycle Outcomes

open access: green, 2023
Qi Wan   +12 more
openalex   +1 more source

Human Recombinant FSH and Its Biosimilars: Clinical Efficacy, Safety, and Cost-Effectiveness in Controlled Ovarian Stimulation for In Vitro Fertilization [PDF]

open access: gold, 2020
Loredana Bergandi   +7 more
openalex   +1 more source

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

open access: yesAdvanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang   +15 more
wiley   +1 more source

In vitro fertilization of porcine oocytes is affected by spermatic coincubation time [PDF]

open access: gold, 2016
Guilherme Oberlender   +7 more
openalex   +1 more source

Thermosensory TRPV Heterotetramers Drive Seasonal Polyphenism: Molecular Basis of CcIav/CcNan‐PKCα‐AKH/AKHR Signaling in Pear Psyllid Morph Transition

open access: yesAdvanced Science, EarlyView.
At 2 5 °C, thermal activation initiates: i) CcIav/CcNan heterotetramer assembly → Ca2⁺ influx; ii) CcPKCα phosphorylation → AKH signaling potentiation; iii) CcAKH1 binding to membrane‐localized CcAKHR → energy mobilization (lipid catabolism/glycogenolysis) and vitellogenin transport via follicular patency; iv) Oocyte maturation → summer‐form nymph ...
Jianying Li   +6 more
wiley   +1 more source

Efficacy of Dual Triggering Versus hCG in Consecutive IVF Cycles in Women with Poor Ovarian Response

open access: yesBezmiâlem Science
Objective: Bolus administration of gonadotrophin-releasing hormone (GnRH) analogs (GnRH-a) mimics physiological ovulation and reduces the risk of ovarian hyperstimulation syndrome.
Melis Gökçe KOÇER YAZICI   +5 more
doaj   +1 more source

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