Results 91 to 100 of about 805,984 (229)

Current Aspects of siRNA Bioconjugate for In Vitro and In Vivo Delivery

Molecules, 2019
Studies on siRNA delivery have seen intense growth in the past decades since siRNA has emerged as a new class of gene therapeutics for the treatment of various diseases. siRNA bioconjugate, as one of the major delivery strategies, offers the potential to
Wanyi Tai
semanticscholar   +1 more source

Nanoparticle drug delivery systems for inner ear therapy: An overview [PDF]

, 2017
open7noembargoed_20180701Valente, Filippo; Astolfi, Laura; Simoni, Edi; Danti, Serena; Franceschini, Valeria; Chicca, Milvia; Martini, AlessandroValente, Filippo; Astolfi, Laura; Simoni, Edi; Danti, Serena; Franceschini, Valeria; Chicca, Milvia; Martini,
Astolfi, Laura, Chicca, Milvia, DANTI, SERENA, Franceschini, Valeria, Martini, Alessandro, Simoni, Edi, Valente, Filippo   +6 more
core   +2 more sources

Extension of the in vivo half-life of endostatin and its improved anti-tumor activities upon fusion to a humanized antibody against tumor-associated glycoprotein 72 in a mouse model of human colorectal carcinoma

OncoTarget, 2015
Endostatin is an endogenous angiogenesis inhibitor that exhibits potential anti-tumor efficacy in various preclinical animal models. However, its relatively short in vivo half-life and the long-term, frequent administration of high doses limit its ...
Sang-hyun Lee, I. Jeung, T. W. Park, Kyungmin Lee, D. G. Lee, Young‐Lai Cho, T. Lee, Hee-Jun Na, Young-Jun Park, Hee-Gu Lee, Munsik Jeong, K. Bae, Sang Chul Lee, H. Lee, Young-Guen Kwon, H. Hong, Jang‐Seong Kim, J. Min   +17 more
semanticscholar   +1 more source

APX001 Is Effective in the Treatment of Murine Invasive Pulmonary Aspergillosis. [PDF]

, 2019
Invasive pulmonary aspergillosis (IPA) due to Aspergillus fumigatus is a serious fungal infection in the immunosuppressed patient population. Despite the introduction of new antifungal agents, mortality rates remain high, and new treatments are needed ...
Alkhazraji, Sondus, Alqarihi, Abdullah, Gebremariam, Teclegiorgis, Gu, Yiyou, Ibrahim, Ashraf S, Jeon, Heewon H, Kapoor, Mili, Shaw, Karen J   +7 more
core  

Clinical disposition, metabolism and in vitro drug–drug interaction properties of omadacycline

Xenobiotica; the fate of foreign compounds in biological systems, 2017
1. Absorption, distribution, metabolism, transport and elimination properties of omadacycline, an aminomethylcycline antibiotic, were investigated in vitro and in a study in healthy male subjects. 2.
J. Flarakos, Yancy Du, Helen Gu, Lai Wang, H. Einolf, D. Y. Chun, B. Zhu, N. Alexander, Adrienne Natrillo, Imad Hanna, Lillian S. L. Ting, W. Zhou, K. Dole, Haiying Sun, S. J. Kovacs, D. Stein, S. Tanaka, S. Villano, J. Mangold   +18 more
semanticscholar   +1 more source

A single mutation in the envelope protein modulates flavivirus antigenicity, stability, and pathogenesis [PDF]

, 2017
The structural flexibility or 'breathing' of the envelope (E) protein of flaviviruses allows virions to sample an ensemble of conformations at equilibrium.
Diamond, Michael S, Dowd, Kimberly A, Goo, Leslie, Pierson, Theodore C, VanBlargan, Laura A   +4 more
core   +5 more sources

Equine sarcoids: Bovine Papillomavirus type 1 transformed fibroblasts are sensitive to cisplatin and UVB induced apoptosis and show aberrant expression of p53 [PDF]

, 2012
Bovine papillomavirus type 1 infects not only cattle but also equids and is a causative factor in the pathogenesis of commonly occurring equine sarcoid tumours.
Campo, M., Finlay, M., Morgan, I.M., Nasir, L., Yuan, Z.   +4 more
core   +3 more sources

Inhibition of Tacrolimus Metabolism by Cannabidiol and Its Metabolites In Vitro

Clinical and Translational Science
Drug interactions are major causes of interindividual variability in tacrolimus exposure and effect. Tacrolimus, a widely used drug in transplant patients, is metabolized by CYP3A4 and CYP3A5. Cannabidiol (CBD) use after transplant is common.
Gerald C. So, Jessica Bo Li Lu, Ying‐Hua Cheng, Debora L. Gisch, Sachiko Koyama, Ricardo Melo Ferreira, Travis R. Beamon, Zeruesenay Desta, Michael T. Eadon   +8 more
doaj   +1 more source

Efficacies and ADME properties of redox active methylene blue and phenoxazine analogues for use in new antimalarial triple drug combinations with amino-artemisinins

Frontiers in Pharmacology
Efforts to develop new artemisinin triple combination therapies effective against artemisinin-tolerant strains of Plasmodium falciparum based on rational combinations comprising artemisone or other amino-artemisinins, a redox active drug and a third drug
Daniel J. Watson, Lizahn Laing, Jacobus P. Petzer, Ho Ning Wong, Christopher J. Parkinson, Lubbe Wiesner, Richard K. Haynes, Richard K. Haynes   +7 more
doaj   +1 more source

In vitro propagation of Anathallis adenochila (Loefgr.) F. Barros (Orchidaceae), a species endemic to southern and southeastern Brazil

Acta Botânica Brasílica, 2014
Anathallis adenochila is a small epiphytic orchid, endemic to the Atlantic Forest in the southern and southeastern regions of Brazil. Information on the species is scarce and limited to distribution and occurrence data, with no reports about its ...
Delio Endres Júnior, Márcio Hisayuki Sasamori, Annette Droste   +2 more
doaj   +1 more source