Multivalent Antiviral XTEN–Peptide Conjugates with Long in Vivo Half-Life and Enhanced Solubility
Bioconjugate chemistry, 2014 XTENs are unstructured, nonrepetitive protein polymers designed to prolong the in vivo half-life of pharmaceuticals by introducing a bulking effect similar to that of poly(ethylene glycol). While XTEN can be expressed as a recombinant fusion protein with
S. Ding +15 more
semanticscholar +1 more source
Two-year follow-up of macaques developing intermittent control of the human immunodeficiency virus homolog simian immunodeficiency virus SIVmac251 in the chronic phase of infection [PDF]
, 2015 Off-therapy control of viremia by HIV-infected individuals has been associated with two likely players: a restricted viral reservoir and an efficient cell-mediated immune response.
Arts, Eric +14 more
core +2 more sources
In vitro and in vivo stability of a highly efficient long-acting cocaine hydrolase
Scientific ReportsIt is recognized as a promising therapeutic strategy for cocaine use disorder to develop an efficient enzyme which can rapidly convert cocaine to physiologically inactive metabolites.
Linyue Shang +9 more
doaj +1 more source
Human pharmacokinetics and CSF penetration of clavulanic acid [PDF]
, 2017 Clavulanic acid, a product of Streptomyces clavuligerus with β-lactam structure, is a potent inhibitor of several β-lactamases. To study its pharmacokinetic and CSF penetration in patients without meningeal inflammation, a single oral dose of 250 mg of ...
Blaser, J. +3 more
core
, 2016 We report on the synthesis, characterization, stability and pharmacokinetics of novel iron based contrast agents for magnetic resonance imaging (MRI). Statistical copolymers combining multiple phosphonic acid groups and poly(ethylene glycol) (PEG) were ...
Berret, J. -F. +6 more
core +3 more sources
In vitro and in vivo Antidiabetic Properties of Phenolic Antioxidants From Sedum adenotrichum
Frontiers in Nutrition, 2019 Natural products serve as the mainstay of human life, and today, almost half of the drugs in clinical practice are the natural origin. Keeping in view the importance of medicinal plants and natural products, Sedum adenotrichum also known as Rosularia ...
D. Naz +3 more
semanticscholar +1 more source
International Journal of Nanomedicine, 2014 Purpose As a potential protein therapeutic for type 2 diabetes mellitus (T2DM), BAY 55-9837 is limited by poor stability and a very short half-life in vivo.
Lei Rao +5 more
semanticscholar +1 more source
Crosslinking of micropatterned collagen-based nerve guides to modulate the expected half-life.
Journal of Biomedical Materials Research. Part A, 2014 The microstructural, mechanical, compositional, and degradative properties of a nerve conduit are known to strongly affect the regenerative process of the injured peripheral nerve.
L. Salvatore +4 more
semanticscholar +1 more source
Pharmacokinetic Herb-Drug Interactions: Insight into Mechanisms and Consequences [PDF]
, 2015 Herbal medicines are currently in high demand, and their popularity is steadily increasing. Because of their perceived effectiveness, fewer side effects and relatively low cost, they are being used for the management of numerous medical conditions ...
Horie, Toshiharu +3 more
core +1 more source
Mutacin 1140 Lantibiotic Variants Are Efficacious Against Clostridium difficile Infection
Frontiers in Microbiology, 2018 Lantibiotics offer an untapped pipeline for the development of novel antibiotics to treat serious Gram-positive (+) infections including Clostridium difficile.
Johan A. Kers +7 more
doaj +1 more source