Results 111 to 120 of about 805,984 (229)

Novel 4-Acrylamido-Quinoline Derivatives as Potent PI3K/mTOR Dual Inhibitors: The Design, Synthesis, and in vitro and in vivo Biological Evaluation

Frontiers in Chemistry, 2019
A novel structural series of quinoline derivatives were designed, synthesized and biologically evaluated as PI3K/mTOR dual inhibitors upon incorporation of C-4 acrylamide fragment.
Xiaodong Ma, Li Shen, Jiankang Zhang, Guoqiang Liu, Shuyu Zhan, Baoyue Ding, Xiaoqing Lv   +6 more
semanticscholar   +1 more source

A Single Amino Acid Substitution in the Antimicrobial Defense Protein Cecropin B Is Associated with Diminished Degradation by Leaf Intercellular Fluid

Molecular Plant-Microbe Interactions, 1997
Degradation is one of several factors that may affect the level of accumulation of transgene products in plants. In plants engineered to secrete antimicrobial proteins to the intercellular compartment of leaves, the degradative activity of proteases ...
Lowell D. Owens, Thomas M. Heutte
doaj   +1 more source

Prediction of Turbulent Shear Stresses through Dysfunctional Bileaflet Mechanical Heart Valves using Computational Fluid Dynamics

, 2018
There are more than 300,000 heart valves implanted annually worldwide with about 50% of them being mechanical valves. The heart valve replacement is often a common treatment for severe valvular disease.
Gamage, Peshala T., Khalili, Fardin, Mansy, Hansen   +2 more
core   +1 more source

PREPARATION, IN VITRO AND IN VIVO CHARACTERIZATION OF HYDROPHOBIC PATCHES OF A HIGHLY WATER SOLUBLE DRUG FOR PROLONGED PLASMA HALF LIFE: EFFECT OF PERMEATION ENHANCERS.

Acta poloniae pharmaceutica, 2018
Aim of present study was to develop metoprolol matrix patches using different enhancers. Combination of two hydrophobic polymers, ethyl cellulose and eudragit RL 100 (8 : 2) were used for preparation of unilaminated matrix patch. 10% w/w of isopropyl myristate (IPM), dimethyl sulfoxide (DMSO), span (20 (S20), Tween 20 (T20) and eucalyptus oil as ...
Ayesha, Yaqoob, Mahmood, Ahmad, Asif, Mahmood, Rai Muhammad, Sarfraz   +3 more
openaire   +1 more source

Sialylation of IgE reduces FcεRIα interaction and mast cell and basophil activation in vitro and increases IgE half‐life in vivo

Allergy, 2023
Lara Dühring, Janina Petry, Gina‐Maria Lilienthal, Yannic C. Bartsch, Marie Kubiak, Clarissa Pfeufer, Selina Lehrian, Jana S. Buhre, Hanna B. Lunding, Carsten Kern, Jochen Behrends, Theresa Walsemann, Leonie Gädert, Charline Sommer, Lynn Krüger, Véronique Blanchard, Susann Dehmel, Uta Jappe, Johann Rahmöller, Marc Ehlers   +19 more
openaire   +2 more sources

An Investigation of the Efficacy of Curcumin for Treatment of Alzheimer\u27s Disease [PDF]

, 2016
Curcumin is the primary curcuminoid found in the rhizome of the turmeric plant (Curcuma longa), responsible for the spice’s distinctive yellow color. Research conducted within the past two decades suggests that the compound may be an effective treatment ...
Patel, Parantap
core   +1 more source

In vitro potency and pharmacokinetics of APG777, a novel anti–IL-13 mAb

Journal of Allergy and Clinical Immunology: Global
Background: IL-13 plays a key role in the induction and perpetuation of type 2 immune responses associated with the development of atopic dermatitis and other chronic inflammatory diseases.
Eric Zhu, PhD, Holly Prentice, PhD, Jason Oh, PhD, Hussam Shaheen, PhD, Namita A. Gandhi, PhD, Grant Wickman, PhD, Rebecca Dabora, PhD, Carl L. Dambkowski, MD, Lukas Dillinger, PhD   +8 more
doaj   +1 more source

Relations of environmental contaminants, algal toxins, and diet with the reproductive success of American alligators on Florida Lakes [PDF]

, 2001
(113 page ...
Arnold, Beverly S., Gross, Timothy S., McDonald, Kelly, Spulveda, Maria S.   +3 more
core  

Actinidin treatment and sous vide cooking : effects on tenderness and in vitro protein digestibility of beef brisket : a thesis presented in partial fulfilment of the requirements for the degree of Master of Food Technology at Massey University, Manawatū, New Zealand [PDF]

, 2017
Actinidin from kiwifruit can tenderise meat and help to add value to low-value meat cuts. Compared with other traditional tenderisers (e.g. papain and bromelain) it is a promising way, due to its less intensive tenderisation effects on meat.
Zhu, Xiaojie
core  

The influence of portal blood upon lipid metabolism in normal and diabetic dogs and baboons [PDF]

, 1975
It has been reported that hyperlipidemia can be alleviated in human beings with an end to side portacaval shunt. Understanding the mechanism of the effect has important implications, including the possibility of devising other ways of lowering serum ...
Lee, IY, Porter, KA, Putnam, CW, Starzl, TE   +3 more
core