Results 141 to 150 of about 423,855 (249)

Artesunate repurposing for cytomegalovirus management: a systematic review of efficacy, mechanisms, and perspectives. [PDF]

Front Cell Infect Microbiol
Zhang H, Zhou F, Song J, Deng C, He X, Ni S.   +5 more
europepmc   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Failure of endophthalmitis prophylaxis: laboratory model comparing antibiotics and bacterial loads. [PDF]

J Cataract Refract Surg
Moon M, Mathews S, Mahjabin F, Karaiskos K, Libre PE.   +4 more
europepmc   +1 more source

A Review on Catalytic Nanostructured Electrodes for Wearable and Implantable Abiotic Glucose Fuel Cells

Advanced Science, EarlyView.
This review identifies current and future directions in abiotic nanostructured catalysts to develop reliable and sustainable glucose fuel cells to power the next generation of bioelectronic devices. ABSTRACT The global rise in incidence of chronic diseases has led to the demand for innovative solutions that help patients manage their conditions with ...
Asghar Niyazi, Hannah S. Leese, Benjamin Metcalfe, Mirella Di Lorenzo   +3 more
wiley   +1 more source

Clinical and research applications of fibroblast activation protein-α inhibitor tracers: a review. [PDF]

Br J Radiol
Desaulniers M, Rousseau É, Pabst KM.
europepmc   +1 more source

Intracellular half-life of cisplatin in malignant cells : A kinetic study of the decline rate of intracellular cisplatin concentration in in-vitro grown cells determined by LC-ICP-MS following exposure to clinically relevant cisplatin doses

, 2011
Cisplatin is a common cancer therapy substance used against several types of malignant tumors and often shows great efficiency. The most important tumour killing mechanism is believed to be formation of Pt-DNA adducts. It is however a common phenomenon that tumors develop resistance causing inefficient treatment.
openaire   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source

Data-driven model reveals increased stability of CAG-expanded huntingtin RNA due to MID1 binding. [PDF]

PLoS Comput Biol
Liu Y, Reisbitzer A, Dorešić D, Hasenauer J, Krauß S, Tchumatchenko T.   +5 more
europepmc   +1 more source

RBM10 Deficiency Promotes Anti‐PD‐1 Resistance in LUAD via STING Alternative Splicing‐Driven CCL7 Signaling and Macrophage Polarization

Advanced Science, EarlyView.
RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao, Ruqiong Wang, Bo An, Lishuang Qi, Zihan Jing, Xingmei Ren, Yang Zhou, Mingjun Xu, Jiaojiao Li, Jie Liu, Liying Wang, Gang Xu, Rou Li, Dexin Jia, Yan Yu   +14 more
wiley   +1 more source

Strategies to overcome hepatic clearance of endogenous proteins - molecular and formulation approaches. [PDF]

RSC Chem Biol
Meiners K, Stepic T, Meinel L, Lühmann T.   +3 more
europepmc   +1 more source