Results 21 to 30 of about 805,984 (229)

An UPLC–ESI–MS/MS Bioanalytical Methodology for the Quantification of Gilteritinib in Human Liver Microsomes: Application to In Vitro and In Silico Metabolic Stability Estimation

Separations, 2023
Gilteritinib (Xospata®) is a tyrosine kinase inhibitor (TKI) that works by inhibiting numerous receptor tyrosine kinases, involving AXL and FMS-like tyrosine kinase 3 (FLT3).
Mohamed W. Attwa, Haitham AlRabiah, Aishah M. Alsibaee, Ali S. Abdelhameed, Adnan A. Kadi   +4 more
doaj   +1 more source

Development and Validation of a Rapid LC-MS/MS Method for Quantifying Alvocidib: In Silico and In Vitro Metabolic Stability Estimation in Human Liver Microsomes

Molecules, 2023
Alvocidib (AVC; flavopiridol) is a potent cyclin-dependent kinase inhibitor used in patients with acute myeloid leukemia (AML). The FDA has approved orphan drug designation to AVC for treating patients with AML.
Mohamed W. Attwa, Haitham AlRabiah, Adnan A. Kadi   +2 more
doaj   +1 more source

An Ultrafast UPLC–MS/MS Method for Characterizing the In Vitro Metabolic Stability of Acalabrutinib

Molecules, 2023
Acalabrutinib, commercially known as Calquence®, is a pharmacological molecule that has robust inhibitory activity against Bruton tyrosine kinase. The medicine in question was carefully developed by the esteemed pharmaceutical company AstraZeneca.
Mohamed W. Attwa, Ahmed H. Bakheit, Ali S. Abdelhameed, Adnan A. Kadi   +3 more
doaj   +1 more source

Single daily dosing of antibiotics: importance of in vitro killing rate, serum half-life, and protein binding [PDF]

Antimicrobial Agents and Chemotherapy, 1991
The relative importance of pharmacokinetic and pharmacodynamic parameters for the feasibility of a single daily dose (SDD) of antibiotics remains to be established. Therefore, we studied the relationship between in vitro bacteriological parameters (MIC, MBC, and killing rate [KR], defined as the reduction in the inoculum within 3 h), pharmacokinetic ...
G, Potel, N P, Chau, B, Pangon, B, Fantin, J M, Vallois, F, Faurisson, C, Carbon   +6 more
openaire   +2 more sources

Selection of bispecific antibodies with optimal developability using FcRn‑pH‑HPLC as an optimized FcRn affinity chromatography method

mAbs, 2023
A challenge when developing therapeutic antibodies is the identification of candidates with favorable pharmacokinetics (PK) early in development. A key determinant of immunoglobulin (IgG) serum half‑life in vivo is the efficiency of pH-dependent binding ...
Thomas Müller, Carolin Tasser, Michael Tesar, Ivica Fucek, Ute Schniegler-Mattox, Joachim Koch, Kristina Ellwanger   +6 more
doaj   +1 more source

The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2

bioRxiv, 2022
Sotrovimab (VIR-7831) and VIR-7832 are dual action monoclonal antibodies (mAbs) targeting the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
A. Cathcart, C. Havenar-Daughton, Florian A. Lempp, Da Ma, M. A. Schmid, Maria L. Agostini, B. Guarino, J. di Iulio, Laura E. Rosen, H. Tucker, J. Dillen, Sambhavi Subramanian, B. Sloan, S. Bianchi, D. Pinto, C. Saliba, K. Culap, Jason A. Wojcechowskyj, Julia Noack, Jiayi Zhou, Hannah Kaiser, Arthur Chase, Martin Montiel-Ruiz, E. Dellota, A. Park, R. Spreafico, A. Sahakyan, Elvin J Lauron, N. Czudnochowski, E. Cameroni, S. Ledoux, A. Werts, C. Colas, L. Soriaga, A. Telenti, L. Purcell, Seungmin Hwang, G. Snell, H. Virgin, D. Corti, C. Hebner   +40 more
semanticscholar   +1 more source

Erythrocytes as Carriers of Therapeutic Enzymes. [PDF]

, 2020
Therapeutic enzymes are administered for the treatment of a wide variety of diseases. They exert their effects through binding with a high affinity and specificity to disease-causing substrates to catalyze their conversion to a non-noxious product, to ...
Bax, BE
core   +1 more source

Effects of Flow Hydrodynamics and Eye Movements on Intraocular Drug Clearance

Pharmaceutics, 2022
New in vitro prototypes (PK-Eye™) were tested with and without eye movement to understand diffusion and convection effects on intraocular clearance. Port placement in front ((i) ciliary inflow model) and behind the model lens ((ii) posterior inflow model)
Angeliki Velentza-Almpani, Nkiruka Ibeanu, Tianyang Liu, Christopher Redhead, Peng Tee Khaw, Steve Brocchini, Sahar Awwad, Yann Bouremel   +7 more
doaj   +1 more source

In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis [PDF]

, 2014
Although hematopoietic precursor activity can be generated in vitro from human embryonic stem cells, there is no solid evidence for the appearance of multipotent, self-renewing and transplantable hematopoietic stem cells.
De Bleser, Dominique, De Mulder, Katrien, Kerre, Tessa, Lambrecht, Bart, Leclercq, Georges, Menten, Björn, Philippé, Jan, Taghon, Tom, Van Caeneghem, Yasmine, Van Roy, Nadine, Vandekerckhove, Bart, Vanhee, Stijn, Velghe, Imke, Verstichel, Greet   +13 more
core   +3 more sources

Melatonin loaded PLGA nanoparticles effectively ameliorate the in vitro maturation of deteriorated oocytes and the cryoprotective abilities during vitrification process.

Biomaterials Science, 2023
Almost all cells can be exposed to stress, but oocytes, which are female germ cells, are particularly vulnerable to damage. In this study, melatonin, a well-known antioxidant, was loaded into biodegradable poly(lactic-co-glycolic acid) (PLGA ...
SuJin Lee, Hye Jin Kim, Hui Bang Cho, Hye-Ryoung Kim, Sujeong Lee, Ji-In Park, Keun‐Hong Park   +6 more
semanticscholar   +1 more source