Results 31 to 40 of about 805,984 (229)

Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging [PDF]

, 2006
Small interfering RNA (siRNA) molecules are potent effectors of post-transcriptional gene silencing. Using noninvasive bioluminescent imaging and a mathematical model of siRNA delivery and function, the effects of target-specific and treatment-specific ...
Bartlett, Derek W., Davis, Mark E.
core   +1 more source

Controlling evolution of protein corona: a prosperous approach to improve chitosan-based nanoparticle biodistribution and half-life

Scientific Reports, 2020
Protein corona significantly affects in vivo fate of nanoparticles including biodistribution and half-life. Without manipulating the physicochemical properties of nanoparticles with considering their biointerference, attaining effective treatment ...
F. M. Tekie, Maliheh Hajiramezanali, P. Geramifar, Mohammad Raoufi, R. Dinarvand, M. Soleimani, F. Atyabi   +6 more
semanticscholar   +1 more source

99mTc-labelled S-HYNIC certolizumab pegol in rheumatoid arthritis and spondyloarthritis patients : a biodistribution and dosimetry study [PDF]

, 2016
Background: Biologicals directed against tumour necrosis factor (TNF) have proven their efficacy in the treatment of spondyloarthritis and rheumatoid arthritis.
Bacher, Klaus, Beyaert, Rudi, Carron, Philippe, D'Asseler, Yves, De Vos, Filip, Dumolyn, Caroline, Elewaut, Dirk, Lambert, Bieke, Van den Bosch, Filip, Verbruggen, August   +9 more
core   +2 more sources

Single-domain antibodies and their formatting to combat viral infections [PDF]

, 2018
Since their discovery in the 1990s, single-domain antibodies (VHHs), also known as NanobodiesA (R), have changed the landscape of affinity reagents. The outstanding solubility, stability, and specificity of VHHs, as well as their small size, ease of ...
Ballegeer, Marlies, De Vlieger, Dorien, Rossey, Iebe, Saelens, Xavier, Schepens, Bert   +4 more
core   +2 more sources

Thermal Effects on Fluid Mixing in the Eye [PDF]

, 2021
Age-related macular degeneration (AMD) is the leading cause of central vision loss in the developed world. Wet AMD can be managed through serial intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF) agents. However, sometimes the
Gharib, Morteza, Huang, Jinglin
core  

Fluoxetine: a case history of its discovery and preclinical development [PDF]

, 2014
Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N, Bergstrom RF, Bravo L, Bremner JD, Burrows GD, Chouinard G, Datla KP, Esther Berrocoso, Juan Antonio Mico, Kreiss DS, Laura Perez-Caballero, Lemberger L, Li Q, Lidia Bravo, Maj J, Nibuya M, Owens MJ, Rutter JJ, Sonia Torres-Sanchez, Stevens JC, Wong DT   +20 more
core   +2 more sources

EDP-938, a novel nucleoprotein inhibitor of respiratory syncytial virus, demonstrates potent antiviral activities in vitro and in a non-human primate model

PLoS Pathogens, 2021
EDP-938 is a novel non-fusion replication inhibitor of respiratory syncytial virus (RSV). It is highly active against all RSV-A and B laboratory strains and clinical isolates tested in vitro in various cell lines and assays, with half-maximal effective ...
Michael H J Rhodin, Nicole McAllister, J. Castillo, S. Noton, R. Fearns, I. Kim, Jianming Yu, Thomas P Blaisdell, Joseph D. Panarese, B. Shook, Y. Or, B. Goodwin, Kai Lin   +12 more
semanticscholar   +1 more source

LC–MS/MS Estimation of Rociletinib Levels in Human Liver Microsomes: Application to Metabolic Stability Estimation

Drug Design, Development and Therapy, 2021
Mohamed W Attwa, Ali S Abdelhameed, Adnan A Kadi Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Ali S Abdelhameed Tel +966 1146 98314Fax +966 1146 76 220Email asaber@ksu.edu ...
Attwa MW, Abdelhameed AS, Kadi AA
doaj  

Antibody-Based In Vivo Imaging of Central Nervous System Targets—Evaluation of a Pretargeting Approach Utilizing a TCO-Conjugated Brain Shuttle Antibody and Radiolabeled Tetrazines

Pharmaceuticals, 2022
Bioorthogonal pretargeted imaging using the inverse-electron-demand Diels–Alder (IEDDA) reaction between a tetrazine (Tz) and a trans-cyclooctene (TCO) represents an attractive strategy for molecular imaging via antibodies.
Christoph Bredack, Martin R. Edelmann, Edilio Borroni, Luca C. Gobbi, Michael Honer   +4 more
doaj   +1 more source

KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation. [PDF]

, 2016
KDM2B (also known as FBXL10) controls stem cell self-renewal, somatic cell reprogramming and senescence, and tumorigenesis. KDM2B contains multiple functional domains, including a JmjC domain that catalyzes H3K36 demethylation and a CxxC zinc-finger that
Feng, X, Guan, K-L, Han, X-R, Lei, Q-Y, Xia, Y-K, Xiong, Y, Yuan, H-X, Zha, Z   +7 more
core   +7 more sources