Results 61 to 70 of about 805,984 (229)

SCD5 restored expression favors differentiation and epithelial-mesenchymal reversion in advanced melanoma [PDF]

, 2018
Our previous data supported a role for the Stearoyl-CoA desaturase (SCD5) in protection against malignancy, whereby it appears to functionally modify tumor stroma impairing tumor spread.
Bellenghi, Maria, Bottero, Lisabianca, Carè, Alessandra, Felicetti, Federica, Gulino, Alessandro, Mattia, Gianfranco, Petrini, Marina, Pontecorvi, Giada, Puglisi, Rossella   +8 more
core   +1 more source

Effects of a recombinant humanized anti‐cocaine monoclonal antibody on the metabolism and distribution of cocaine in vitro and in mice

Pharmacology Research & Perspectives, 2022
The anti‐cocaine monoclonal antibody, h2E2, is a candidate for treating cocaine‐use disorder. h2E2 binds to and sequesters cocaine in the plasma compartment, effectively decreasing cocaine concentrations in the brains of rats and mice.
Mackenzie E. Turner, Hanna N. Wetzel, Dakota B. Zinani, Christopher A. Crutchfield, Andrew B. Norman   +4 more
doaj   +1 more source

Studies on some properties and the half-life of lactate dehydrogenase-linked immunoglobulin complexes forming experimently in vitro.

SEIBUTSU BUTSURI KAGAKU, 1993
臨床上しばしば見られる酵素結合免疫グロブリンのモデル実験としてヒト精製乳酸脱水酵素 (LD) A4およびB4とそれらの抗ヒトLDモノクローナル抗体 (MoAb) 複合体を作製し, これらの若干の特性を調べた. その結果, LD-LD MoAb 複合体の特性は臨床上発見される E-Ig複合体の抗体の性質と類似し, その電気泳動上での移動度もよく一致していた. 本研究では特にLD結合免疫グロブリン複合体形成に関与すると思われる各 MoAbの糖鎖部分について注目し, 各 MoAb を各種グリコシダーゼで処理し, ヒト精製125IラベルLDアイソザイムと結合させた. こうして実験的に作製したLD-LD MoAb 複合体を家兎腹腔中へ注射した.
Masakazu Miura, Hiroshi Sakai, Yoshikatsu Sakagishi, Tsugikazu Komoda   +3 more
openaire   +2 more sources

Site-specific identification and quantitation of endogenous SUMO modifications under native conditions. [PDF]

, 2017
Small ubiquitin-like modifier (SUMO) modification regulates numerous cellular processes. Unlike ubiquitin, detection of endogenous SUMOylated proteins is limited by the lack of naturally occurring protease sites in the C-terminal tail of SUMO proteins ...
Ahmad, Alla S, Bennett, Eric J, Clauser, Karl R, Gu, Hongbo, Komives, Elizabeth A, Leonard, Marilyn, Lumpkin, Ryan J, Meyer, Jesse G, Zhu, Yiying   +8 more
core   +2 more sources

Uptake and fecal excretion of Coxiella burnetii by Ixodes ricinus and Dermacentor marginatus ticks [PDF]

, 2020
Background: The bacterium Coxiella burnetii is the etiological agent of Q fever and is mainly transmitted via inhalation of infectious aerosols. DNA of C.
Henning, Klaus, Körner, Sophia, Makert, Gustavo R., Mertens‑Scholz, Katja, Nijhof, Ard M., Pfeffer, Martin, Starke, Alexander, Ulbert, Sebastian   +7 more
core   +1 more source

Development of [18F]-PSS223 as a PET Tracer for Imaging of Metabotropic Glutamate Receptor Subtype 5 (mGluR5)

CHIMIA, 2012
Involvement of metabotropic glutamate receptor subtype 5 (mGluR5) in physiological and pathophysiological processes in the brain has been demonstrated, and hence mGluR5 has emerged as an important drug target. [11C]-ABP688 is clinically the most
Selena Milicevic Sephton, Patrick Dennler, Dominique S. Leutwiler, Linjing Mu, Roger Schibli, Stefanie D. Krämer, Simon M. Ametamey   +6 more
doaj   +1 more source

Sex hormone-binding globulin regulation of androgen bioactivity in vivo : validation of the free hormone hypothesis [PDF]

, 2016
Sex hormone-binding globulin (SHBG) is the high-affinity binding protein for androgens and estrogens. According to the free hormone hypothesis, SHBG modulates the bioactivity of sex steroids by limiting their diffusion into target tissues.
Antonio, Leen, Blokland, Marco, Carmeliet, Geert, Claessens, Frank, Decallonne, Brigitte, Dubois, Vanessa, Fiers, Tom, Gielen, Evelien, Hammond, Geoffrey L, Huhtaniemi, Ilpo T, Jardí, Ferran, Kaufman, Jean, Khalil, Rougin, Laurent, Michaël R, Sterk, Saskia S, Vanderschueren, Dirk   +15 more
core   +2 more sources

CORM-2-entrapped ultradeformable liposomes ameliorate acute skin inflammation in an ear edema model via effective CO delivery

Acta Pharmaceutica Sinica B, 2020
The short release half-life of carbon monoxide (CO) is a major obstacle to the effective therapeutic use of carbon monoxide-releasing molecule-2 (CORM-2).
Gwan-Yeong Lee, Alam Zeb, Eun-Hye Kim, Beomseon Suh, Young-Jun Shin, Donghyun Kim, Kyoung-Won Kim, Yeong-Hwan Choe, Ho-Ik Choi, Cheol-Ho Lee, Omer Salman Qureshi, In-Bo Han, Sun-Young Chang, Ok-Nam Bae, Jin-Ki Kim   +14 more
doaj   +1 more source

Formation and Function of the Rbl2p-beta-Tubulin Complex [PDF]

, 1998
The yeast protein Rbl2p suppresses the deleterious effects of excess beta-tubulin as efficiently as does alpha-tubulin. Both in vivo and in vitro, Rbl2p forms a complex with beta-tubulin that does not contain alpha-tubulin, thus defining a second pool of
Archer, Julie E., Magendantz, Margaret, Solomon, Frank, Vega, Leticia R.   +3 more
core  

Future of 5-fluorouracil in cancer therapeutics, current pharmacokinetics issues and a way forward [PDF]

, 2019
Background: In addition to exhibiting antitumor potential, antitumor drugs exhibit toxicity due to a poor pharmacokinetic profile. An enormous amount of research has been carried out and is still ongoing to obtain more targeted, potent, and safe drugs to
Abd-Rabou, Anitha, Arias, Atrián-Blasco, Berners-Price, Bertrand, Carrillo, Chandran, Chibaudel, Clingan, DiGiulio, Esin, Gao, Gasser, Hoste, Li, Liu, Liu, Luo, Miura, Mohana, Moloney, Nadzri, Nisa, Nivethaa, Nunes, Rambabu, Rengaraj, Saǧir, Shaima, Shen, Subudhi, Sun, Tummala, Wang, Yu, Zhang, Zhang, Zhu, Álvarez   +39 more
core   +1 more source