Results 71 to 80 of about 805,984 (229)

Extended half-life target module for sustainable UniCAR T-cell treatment of STn-expressing cancers

Journal of Experimental & Clinical Cancer Research, 2020
Background Adapter chimeric antigen receptor (CAR) approaches have emerged has promising strategies to increase clinical safety of CAR T-cell therapy. In the UniCAR system, the safety switch is controlled via a target module (TM) which is characterized ...
Liliana R. Loureiro, Anja Feldmann, Ralf Bergmann, Stefanie Koristka, Nicole Berndt, Domokos Máthé, Nikolett Hegedüs, Krisztián Szigeti, Paula A. Videira, Michael Bachmann, Claudia Arndt   +10 more
doaj   +1 more source

The extended recovery ring-stage survival assay provides a superior association with patient clearance half-life and increases throughput

Malaria Journal, 2020
Background Tracking and understanding artemisinin resistance is key for preventing global setbacks in malaria eradication efforts. The ring-stage survival assay (RSA) is the current gold standard for in vitro artemisinin resistance phenotyping.
Sage Z. Davis, Puspendra P. Singh, Katelyn M. Vendrely, Douglas A. Shoue, Lisa A. Checkley, Marina McDew-White, Katrina A. Button-Simons, Zione Cassady, Mackenzie A. C. Sievert, Gabriel J. Foster, François H. Nosten, Timothy J. C. Anderson, Michael T. Ferdig   +12 more
doaj   +1 more source

In Vitro–In Vivo Correlation of Tianeptine Sodium Sustained-Release Dual-Layer Tablets

Molecules, 2022
Tianeptine tablets are currently marketed to be designed for immediate-release tablets. The tianeptine has a short half-life, making it difficult to design for sustained-release tablets and achieve bioequivalence with the tianeptine immediate-release ...
Ye-Ji Lee, Joo-Eun Kim
doaj   +1 more source

Human cellular CYBA UTR sequences increase mRNA translation without affecting the half-life of recombinant RNA transcripts

Scientific Reports, 2016
Modified nucleotide chemistries that increase the half-life (T1/2) of transfected recombinant mRNA and the use of non-native 5′- and 3′-untranslated region (UTR) sequences that enhance protein translation are advancing the prospects of transcript therapy.
M. Ferizi, M. Aneja, E. R. Balmayor, Z. S. Badieyan, O. Mykhaylyk, C. Rudolph, C. Plank   +6 more
semanticscholar   +1 more source

E5 protein of human papillomavirus 16 downregulates HLA class I and interacts with the heavy chain via its first hydrophobic domai [PDF]

, 2006
Human papillomavirus type 16 E5 protein (HPV-16 E5) is expressed early in papillomavirus infection and is localised primarily in the cell Golgi apparatus (GA) and endoplasmic reticulum. E5 prevents transport of the major histocompatibility class I (MHC I;
Adam, Alonso, Araibi, Ashrafi, Ashrafi, Auvinen, Bubb, Chang, Cohen, Conrad, Cresswell, Dickie, Disbrow, Faccini, Fackler, Frazer, Goldstein, Hwang, Kasper, Kell, Lu, Marchetti, Marchetti, Rodriguez, Straight, Straight, Suprynowicz, Thomsen, Williams, Williams, zur Hausen   +30 more
core   +1 more source

Assessment of the in vitro metabolic stability of CEP-37440, a selective FAK/ALK inhibitor, in HLMs using fast UPLC–MS/MS method: in silico metabolic lability and DEREK alerts screening

Frontiers in Chemistry
IntroductionCEP-37440 was synthesized and supplied by the research and development division of Teva Branded Pharmaceutical Products (West Chester, PA, United States). CEP-37440 represents a newly developed compound that exhibits selectivity inhibition of
Mohamed W. Attwa, Haitham AlRabiah, Ali S. Abdelhameed, Adnan A. Kadi   +3 more
doaj   +1 more source

Defining the in vivo phenotype of artemisinin-resistant falciparum malaria: a modelling approach.

PLoS Medicine, 2015
BackgroundArtemisinin-resistant falciparum malaria has emerged in Southeast Asia, posing a major threat to malaria control. It is characterised by delayed asexual-stage parasite clearance, which is the reference comparator for the molecular marker 'Kelch
Lisa J White, Jennifer A Flegg, Aung Pyae Phyo, Ja Hser Wiladpai-ngern, Delia Bethell, Christopher Plowe, Tim Anderson, Standwell Nkhoma, Shalini Nair, Rupam Tripura, Kasia Stepniewska, Wirichada Pan-Ngum, Kamolrat Silamut, Ben S Cooper, Yoel Lubell, Elizabeth A Ashley, Chea Nguon, François Nosten, Nicholas J White, Arjen M Dondorp   +19 more
doaj   +1 more source

Oxidative stress, protein glycation and nutrition – interactions relevant to health and disease throughout the lifecycle [PDF]

, 2014
Protein glycation has been studied for over a century now and plays an important role in disease pathogenesis throughout the lifecycle. Strongly related to diabetic complications, glycation of Hb has become the gold standard method for diabetes diagnosis
American Diabetes, Antonis Vlassopoulos, Bhagwat, El-Salem, Emilie Combet, Hao, Hodge, Khaw, Koenig, Maillard, Malickova, Michael E. J. Lean, Monnier, Nicholl, Rothwell, Schmidt, Sell, Vlassara   +17 more
core   +3 more sources

Discrepancies in the in vitro and in vivo role of scavenger receptors in clearance of nanoparticles by Kupffer cells

Precision Nanomedicine, 2018
Nanoparticles are recognized and cleared by Kupffer cells (KCs) in the liver. This process complicates the development of targeted nanoparticles because of significant reduction of number of nanoparticles that can reach target tissues.
Dmitri Simberg, Ernest Groman, Guankui Wang   +2 more
doaj   +1 more source

Synthesis, Biological Evaluation, and Pharmacokinetic Study of Novel Liguzinediol Prodrugs

Molecules, 2013
Liguzinediol (LZDO) ester prodrugs 3–5 were synthesized and evaluated in vitro and in vivo for their potential use in prolonging the half-life of the parent drug LZDO (1a) in vivo.
Long Chen, Lei Chen, Jing Zhang, Hui-Min Bian, Hong-Mei Wen, Wei Li, Zheng Liu, Kun-Di Yang   +7 more
doaj   +1 more source