Stabilization of resveratrol in blood circulation by conjugation to mPEG and mPEG-PLA polymers: investigation of conjugate linker and polymer composition on stability, metabolism, antioxidant activity and pharmacokinetic profile. [PDF]
PLoS ONE, 2015 Resveratrol is naturally occurring phytochemical with diverse biological activities such as chemoprevention, anti-inflammatory, anti-cancer, anti-oxidant. But undergoes rapid metabolism in the body (half life 0.13h).
Basavaraj Siddalingappa +4 more
doaj +1 more source
Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence [PDF]
, 2019 The activation of cellular senescence throughout the lifespan promotes tumor suppression, whereas the persistence of senescent cells contributes to aspects of aging.
Diekman, Brian O. +9 more
core +3 more sources
c-Maf Transcription Factor Regulates ADAMTS-12 Expression in Human Chondrogenic Cells. [PDF]
, 2013 ObjectiveADAMTS (a disintegrin and metalloproteinase with thrombospondin type-1 motif) zinc metalloproteinases are important during the synthesis and breakdown of cartilage extracellular matrix.
Amanatullah, Derek F +4 more
core +2 more sources
Attenuated T cell responses to a high-potency ligand in vivo.
PLoS Biology, 2010 αβ T cell receptor (TCR) recognition of foreign peptides bound to major histocompatibility complex (pMHC) molecules on the surface of antigen presenting cells is a key event in the initiation of adaptive cellular immunity. In vitro, high-affinity binding
Emily Corse +3 more
doaj +1 more source
Pharmaceutics, 2020 The burden associated with frequent injections of current intravitreal (IVT) therapeutics may be reduced by long-acting delivery strategies. Binding to serum albumin has been shown to extend the ocular half-life in rabbits, however, the underlying ...
Simon Hauri +6 more
doaj +1 more source
Sequence composition of disordered regions fine-tunes protein half-life
Nature Structural &Molecular Biology, 2015 The proteasome controls the concentrations of most proteins in eukaryotic cells. It recognizes its protein substrates through ubiquitin tags and initiates degradation at disordered regions within the substrate.
S. Fishbain +8 more
semanticscholar +1 more source
Shared determinants between virus-infected and trinitrophenyl-conjugated H-2-identical target cells detected in cell-mediated lympholysis [PDF]
, 1976 Infection of H-2-identical mice with either lymphocytic choriomeningitis (LCM) virus, vaccinia virus, or paramyxo (Sendai) virus resulted in the generation of specifically sensitized cytotoxic T lymphocytes (CTL).
Bevan +16 more
core +1 more source
Pharmaceutics, 2019 Extrapolation of pharmacokinetic (PK) parameters from in vitro or in vivo animal to human is one of the main tasks in the drug development process. Translational approaches provide evidence for go or no-go decision-making during drug discovery and the ...
Go-Wun Choi +2 more
semanticscholar +1 more source
Tissue-Specific Fluorescent Protein Turnover in Free-Moving Flies
InsectsConditional transgenic systems and multi-copy target transgenes were used to produce transient fluorescent protein expression in adult Drosophila melanogaster, with the goal of developing an in vivo assay of protein turnover.
Katherine S. Bell +13 more
doaj +1 more source
mAbs, 2015 Antibody therapy is a validated treatment approach for several malignancies. All currently clinically applied therapeutic antibodies (Abs) are of the IgG isotype. However, not all patients respond to this therapy and relapses can occur. IgA represents an
S. Meyer +12 more
semanticscholar +1 more source