In vitro binding and receptor-mediated activity of terlipressin at vasopressin receptors V1 and V2
Journal of Experimental Pharmacology, 2017 Khurram Jamil,1 Stephen Chris Pappas,2 Krishna R Devarakonda1 1Clinical Development, Mallinckrodt Pharmaceuticals, Bedminster, 2Orphan Therapeutics, LLC, Lebanon, NJ, USA Abstract: Terlipressin, a synthetic, systemic vasoconstrictor with selective ...
Jamil K, Pappas SC, Devarakonda KR
doaj
Relationship of cognitive decline with glucocerebrosidase activity and amyloid‐beta 42 in DLB and PD
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objective Dementia with Lewy bodies (DLB) and Parkinson's disease (PD) share clinical, pathological, and genetic risk factors, including GBA1 and APOEε4 mutations. Biomarkers associated with the pathways of these mutations, such as glucocerebrosidase enzyme (GCase) activity and amyloid‐beta 42 (Aβ42) levels, may hold potential as predictive ...
Maria Camila Gonzalez +15 more
wiley +1 more source
In Vitro Techniques Using the DaisyII Incubator for the Assessment of Digestibility: A Review. [PDF]
Animals (Basel), 2020 Tassone S, Fortina R, Peiretti PG.
europepmc +1 more source
Development of surgical techniques for preparation of in vitro-isolated perfused porcine skin flaps for percutaneous absorption studies [PDF]
, 1991 Karl F. Bowman +2 more
openalex +1 more source
In Vitro Techniques for ADP-Ribosylated Substrate Identification
, 2018 ADP-ribosylation is a post-translational modification of proteins that has required the development of specific technical approaches for the full definition of its physiological roles and regulation. The identification of the enzymes and specific substrates of this reaction is an instrumental step toward these aims.
Grimaldi Giovanna +3 more
openaire +4 more sources
Unleashing the Power of Multiomics: Unraveling the Molecular Landscape of Peripheral Neuropathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Peripheral neuropathies (PNs) affect over 20 million individuals in the United States, manifesting as a wide range of sensory, motor, and autonomic nerve symptoms. While various conditions such as diabetes, metabolic disorders, trauma, autoimmune disease, and chemotherapy‐induced neurotoxicity have been linked to PN, approximately one‐third of
Julie Choi +7 more
wiley +1 more source
Assisted ejaculation combined with in vitro fertilisation: an effective technique treating male infertility due to spinal cord injury [PDF]
, 1994 Claes Hultling +6 more
openalex +1 more source
Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics
Advanced Biology, EarlyView.This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim +3 more
wiley +1 more source
Quantitative in vitro to in vivo extrapolation for human toxicology and drug development [PDF]
arXivTraditional animal testing for toxicity is expensive, time consuming, ethically questioned, sometimes inaccurate because of the necessity to extrapolate from animal to human, and in most cases not formally validated according to modern standards. This is driving regulatory bodies and companies in backing alternative methods focusing on in silico and in
arxiv
Exploiting the in vitro ovary culture technique to breed rice hybrids [PDF]
, 1998 R. B. Li +3 more
openalex +1 more source