Results 141 to 150 of about 665,099 (218)

Characterization of Promising Cytotoxic Metabolites from Tabebuia guayacan Hemsl.: Computational Prediction and In Vitro Testing. [PDF]

Plants (Basel), 2022
El-Hawary SS, Mohammed R, Taher MA, AbouZid SF, Mansour MA, Almahmoud SA, Huwaimel B, Amin E.   +7 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

<i>In Vitro</i> Testing of Ibrutinib-Loaded Electrospun Nanofibers for Potential Use as a Transdermal Patch Material. [PDF]

ACS Omega
Fil H, Yesiltepe O, Er Zeybekler S, Kozgus O, Kurbanoglu S, Medine EI, Odaci D.   +6 more
europepmc   +1 more source

In vitro testing of a funnel-tip catheter with different clot types to decrease clot migration in mechanical thrombectomy. [PDF]

Interv Neuroradiol, 2023
Payne ES, Krost-Reuhl S, Heimann A, Keric N, Masomi-Bornwasser J, Gerber T, Seidman L, Kirschner S, Brockmann MA, Tanyildizi Y.   +9 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Optimizing stent retrievers for mechanical enhancement and in vitro testing in acute ischemic stroke models. [PDF]

Biomed Eng Online
Lee JW, Kim HK, Kim J, Choi H.
europepmc   +1 more source

Translating the Manufacture of Immunotherapeutic PLGA Nanoparticles from Lab to Industrial Scale: Process Transfer and In Vitro Testing. [PDF]

Pharmaceutics, 2022
Operti MC, Bernhardt A, Pots J, Sincari V, Jager E, Grimm S, Engel A, Benedikt A, Hrubý M, De Vries IJM, Figdor CG, Tagit O.   +11 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

3D printed aligner materials: <i>In vitro</i> testing of biocompatibility, cytotoxicity and antimicrobial activity. [PDF]

Bioinformation
Rajagopal A, Budda KS, Binmuhana NO, Seshagiri R, Shaik MS, Bhogi S.   +5 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source