Results 1 to 10 of about 606,228 (216)
Recent progress and perspectives of continuous in vivo testing device [PDF]
Materials Today Bio, 2022 Devices for continuous in-vivo testing (CIVT) can detect target substances in real time, thus providing a valuable window into a patient's condition, their response to therapeutics, metabolic activities, and neurotransmitter transmission in the brain ...
Tao Ming +11 more
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In vitro Selection and in vivo Testing of Riboswitch-inspired Aptamers [PDF]
Bio-Protocol, 2023 Engineered aptamers for new compounds are typically produced by using in vitro selection methods. However, aptamers that are developed in vitro might not function as expected when introduced into complex cellular environments. One approach that addresses
Michael Mohsen, Ronald Breaker
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Uncovering hidden enhancers through unbiased in vivo testing [PDF]
Nature CommunicationsChromatin signatures are widely used to identify tissue-specific in vivo enhancers, but their sensitivity and specificity remains unclear. Here we show that many developmental enhancers remain undetectable using currently available chromatin data.
Brandon J. Mannion +25 more
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Frontiers in Pharmacology, 2021 Ellagic acid (EA), a fruit- and vegetable-derived flavonoid, has been reported for multiple pharmacological activities, which encouraged us to examine its useful effect in severe malaria pathogenesis, especially malaria-induced cytokine storms and ...
Shilpa Mohanty +9 more
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Antibiotics, 2021 Larvae of the greater wax moth, Galleria mellonella, are a convenient in vivo model for assessing the activity and toxicity of antimicrobial agents and for studying the immune response to pathogens and provide results similar to those from mammals.
Magdalena Piatek +2 more
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Life, 2023 Alzheimer’s disease (AD) is a progressive neurodegenerative disease and is the most common type of dementia. Although a considerably large amount of money has been invested in drug development for AD, no disease modifying treatment has been detected so ...
Kyriaki Savva +10 more
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Nanomaterials, 2022 New forms of cancer treatment, which are effective, have simple manufacturing processes, and easily transportable, are of the utmost necessity. In this work, a methodology for the synthesis of radioactive Gold-198 nanoparticles without the use of ...
Carla Daruich de Souza +10 more
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Predicting chemical hazard across taxa through machine learning
Environment International, 2022 We applied machine learning methods to predict chemical hazards focusing on fish acute toxicity across taxa. We analyzed the relevance of taxonomy and experimental setup, showing that taking them into account can lead to considerable improvements in the ...
Jimeng Wu +5 more
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Open Research Europe, 2022 The aim of this letter is to share the discussions and proposals made by the VAC2VAC consortium on how to support the deployment of the “Consistency Approach” for quality control of established vaccines and thus facilitate the substitution of in vivo ...
Joris Vandeputte +9 more
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A Programmable EEG Monitoring SoC With Optical and Electrical Stimulation for Epilepsy Control
IEEE Access, 2020 In this paper, a cross-domain integration system composed of a gene transfer technique with a pre-clinical trial, an on-chip circuit design, an off-chip hardware with peripheral unit integration, and a custom software is presented.
Shuenn-Yuh Lee +7 more
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