In Vitro Modeling of Natural Killer Cell Cytotoxicity to Inform Personalized ALS Therapeutics
ABSTRACT Objective Natural killer (NK) cells might contribute to motor neuron death in amyotrophic lateral sclerosis (ALS) through direct cytotoxicity, a process that could be inhibited with the FDA‐approved JAK/STAT pathway inhibitor, tofacitinib. This study aimed to verify that tofacitinib can suppress NK cell cytotoxicity, investigate if immune cell
Benjamin J. Murdock+8 more
wiley +1 more source
Model-based translation of the PKPD-relationship for linezolid and vancomycin on methicillin-resistant Staphylococcus aureus: from in vitro time-kill experiments to a mouse pneumonia model. [PDF]
Vera-Yunca D+3 more
europepmc +1 more source
IN VIVO SURVIVAL IN THE HUMAN SUBJECT OF TRANSFUSED ERYTHROCYTES AFTER STORAGE IN VARIOUS PRESERVATIVE SOLUTIONS [PDF]
P. L. Mollison, I. Maureen Young
openalex +1 more source
Discovery and Treatment of Action Potential‐Independent Myotonia in Hyperkalemic Periodic Paralysis
ABSTRACT Objective Hyperkalemic periodic paralysis (hyperKPP) is characterized by attacks of transient weakness. A subset of hyperKPP patients suffers from transient involuntary contraction of muscle (myotonia). The goal of this study was to determine mechanisms causing myotonia in hyperKPP.
Chris Dupont+4 more
wiley +1 more source
Culturing Potential: advances in ex vivo cell culture systems for haematopoietic cell-based regenerative therapies. [PDF]
Sugiyama-Finnis A, Yamazaki S.
europepmc +1 more source
THE TIME REQUIRED FOR REDUCTION OF OXYHEMOGLOBIN IN VIVO
David Fraser Harris+1 more
openalex +1 more source
The growth of micro-organismsin vivowith particular reference to the relation between dose and latent period [PDF]
G. G. Meynell, Elinor Meynell
openalex +1 more source
Multimodal Autonomic Biomarkers Predict Phenoconversion in Pure Autonomic Failure
ABSTRACT Background Pure autonomic failure (PAF) presents with autonomic failure without other neurological features. A third develop central neurological features, fulfilling criteria for multiple system atrophy (MSA) and Lewy body diseases (LBD), including Parkinson's disease and Dementia with Lewy bodies.
S. Koay+12 more
wiley +1 more source
High-Resolution Ultrasound Data for AI-Based Segmentation in Mouse Brain Tumor. [PDF]
Dorosti S+5 more
europepmc +1 more source
Development of in vivo imaging
Kabashima, Kenji, Izuhara, Kenji
openaire +5 more sources