Results 201 to 210 of about 5,806,183 (351)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Re: Tyagi comments on "<i>In situ</i> observation of urothelial responses to NaCl-induced osmotic stress using optical coherence tomography". [PDF]

J Biomed Opt
Wang H, Zhu H.
europepmc   +1 more source

Supplementary Table 1 from A Small-Molecule Inhibitor of Bcl-X_L Potentiates the Activity of Cytotoxic Drugs <i>In vitro</i> and <i>In vivo</i>

, 2023
Alex R. Shoemaker, Anatol Oleksijew, Joy Bauch, Barbara Belli, Tony Borre, Milan Bruncko, Thomas Deckwirth, David J. Frost, Ken Jarvis, Mary K. Joseph, Kennan C. Marsh, William McClellan, Hugh N. Nellans, ShiChung Ng, Paul Nimmer, Jacqueline M. O’Connor, Tilman Oltersdorf, Weiguo Qing, Shen Wang, Jason Stavropoulos, Stephen K. Tahir, Baole Wang, Robert R. Warner, Haichao Zhang, Stephen W. Fesik, Saul H. Rosenberg, Steven W. Elmore   +26 more
openalex   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Nanotechnology-based targeted delivery strategies for the treatment of Alzheimer's disease. [PDF]

Nanoscale Adv
Yuan X, Tang Q, Wang T.
europepmc   +1 more source

Supplementary Table 2 from Quantitative <i>In Vivo</i> Characterization of Intracellular and Extracellular pH Profiles in Heterogeneous Tumors: A Novel Method Enabling Multiparametric pH Analysis

, 2023
Norbert W. Lutz, Yann Le Fur, Johanna Chiche, Jacques Pouysségur, Patrick J. Cozzone   +4 more
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Biodegradable targeted polymeric mRNA nanoparticles enable in vivo CD19 CAR T cell generation and lead to B cell depletion. [PDF]

Sci Adv
Jain M, Est-Witte SE, Shannon SR, Neshat SY, Yu X, Dunham S, Tian T, Cheng L, Harris J, Konig MF, Tzeng SY, Schneck JP, Green JJ.   +12 more
europepmc   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Comparison of 2D and 3D carotid plaque analysis and longitudinal <i>in vivo</i> ultrasound registration using 3D histology. [PDF]

J Med Imaging (Bellingham)
Lee Y, Kiernan MJ, Mitchell CC, Salamat S, Wilbrand SM, Dempsey RJ, Varghese T.   +6 more
europepmc   +1 more source