Results 201 to 210 of about 2,462,763 (267)

Mechanistic interpretations of sustained ventricular fibrillation: The role of mapping methodology, model and time. [PDF]

Heart Int
Tonko JB, Kappadan V, El-Medany A, Aggour H, Zhen H, Birdi A, Pyman E, Barker J, Guichard JB, Clayton RH, Ng FS.   +10 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

A robotic patch-clamp system with real-time localization and phase-synchronized capture of dynamic in vivo cells using micropipette resistance modelling. [PDF]

Microsyst Nanoeng
Li R, Chen H, Hu B, Qiu J, Liu Y, Guo Z, Wu S, Liu M, Ding R, Ding S, Li Y, Pang X, Shen H, Zhao Q, Zhao X.   +14 more
europepmc   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Effects of Xylazole on cAMP and Monoamine Neurotransmitters in Rats: In Vitro and In Vivo. [PDF]

Cells
Hou X, Ma T, Zhao Y, Wang X, Wu Y, Fan H, Zhang S.   +6 more
europepmc   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Low-Strength Type I Interferon Signaling Promotes CAR T-cell Treatment Efficacy. [PDF]

Cancer Immunol Res
Tang E, Hu Y, Cao G, Nguyen DT, Asby NW, Aboelella NS, Ruiz HA, Cai X, Zhang W, Zhao Y, Xie L, Chen X, Bishop MR, Riedell PA, LaBelle JL, Kline JP, Huang J.   +16 more
europepmc   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

MicroRNA-based integrated diagnosis and therapy for GBM: current status and advances. [PDF]

Front Immunol
Chen Y, Liu H, Yuan P, Li Y, Xu C, Li R, Chen J, Wu F.   +7 more
europepmc   +1 more source

Plant Terpenoids in Cardioprotection: An Overview of Their Therapeutic Potential. [PDF]

Curr Issues Mol Biol
Ríos-López JL, Blanco-Salas J, Cumplido-Laso G, Hortigón-Vinagre MP.   +3 more
europepmc   +1 more source