An ingestible device for automated sampling and location tracing in gastrointestinal tract. [PDF]
Li T+19 more
europepmc +1 more source
Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going?
Local anesthetics (LAs), widely used in anesthesia, may also play a role in cancer treatment by inhibiting tumor growth, reducing metastasis, and enhancing immune responses. They modulate key pathways like AKT/mTOR and RAS/ERK while affecting angiogenesis and tumor innervation and the immune response.
Eduardo Nunez‐Rodriguez+3 more
wiley +1 more source
Assessment and mitigation of geometric distortions in Cartesian MR images at 15.2T for preclinical radiation research. [PDF]
Stocchiero S+5 more
europepmc +1 more source
THE CONVERSION IN VIVO OF XYLITOL TO GLYCOGEN VIA THE PENTOSE PHOSPHATE PATHWAY
Donald B. McCormick, Oscar Touster
openalex +1 more source
A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso+5 more
wiley +1 more source
Novel Customizable Fracture Fixation Technique vs. Conventional Metal Locking Plate: An Exploratory Comparative Study of Fixation Stability in an Experimental In Vivo Ovine Bilateral Phalangeal Fracture Model. [PDF]
Colding-Rasmussen T+7 more
europepmc +1 more source
GLYCOGEN FORMATION VIA THE PENTOSE PHOSPHATE PATHWAY IN MICE IN VIVO
Howard H. Hiatt
openalex +1 more source
The novelty of this study showed that the injection of exosomes produced from ADMSCs in combination with Roflumilast poses a more favorable therapeutic outcome for CKD induced by Adriamycin, compared to therapy with exosomes or Roflumilast alone. Roflumilast and exosomes treatment lowered the expression of the apoptotic, fibrotic, and inflammatory ...
Mohamed Ali+5 more
wiley +1 more source
Hydrogel-embedded precision-cut lung slices support ex vivo culture of in vivo-induced premalignant lung lesions. [PDF]
Hauer C+4 more
europepmc +1 more source
Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley +1 more source