Engineering the Link: From Genome Interaction Maps to Functional Insight
Advances in chromosome conformation capture have revealed the genome's 3D organization, yet its causal impact on gene regulation remains elusive. This review highlights emerging genome‐engineering tools ‐ zinc fingers, TALEs, and CRISPR‐Cas9 ‐ that enable targeted manipulation of chromatin loops to dissect structure–function relationships. It discusses
Frido Petersen +5 more
wiley +1 more source
Real-time single-vessel analysis reveals vascular-type-dependent blood-brain barrier dysfunction in rodent models of status epilepticus and neuroinflammation. [PDF]
Kang BM +9 more
europepmc +1 more source
This study reports the fabrication of trabecular bioactive glass scaffolds (composition “1d”: 46.1SiO2‐28.7CaO‐8.8MgO‐6.2P2O5‐5.7CaF2‐4.5Na2O wt%) through vat photopolymerization and the relevant results from mechanical testing and in vivo implantation procedures in rabbit femora, showing great promise for bone tissue engineering applications.
Dilshat Tulyaganov +8 more
wiley +1 more source
Exploring the potential of polymers: advancements in oral nanocarrier technology. [PDF]
Silva RA +4 more
europepmc +1 more source
3D Bioprinting of Thick Adipose Tissues with Integrated Vascular Hierarchies
An advanced 3D bioprinting technique is used here to create thick adipose tissues with a central, vessel and extensive branching. The construct is made using alginate, gelatin and collagen‐based bioinks. Flow through the complex vessel network is demonstrated as well as its successful integration with a femoral artery following implantation in a rat ...
Idit Goldfracht +5 more
wiley +1 more source
Optimizing post brain death vascularized composite graft quality through ex vivo restoration of S-nitrosothiol homeostasis. [PDF]
Zhu L +11 more
europepmc +1 more source
Regulatory roles of LncRNAs in colorectal cancer immune evasion: current concepts and future perspectives. [PDF]
Wang Y +5 more
europepmc +1 more source
Upregulation of metallophore-related genes of community-acquired methicillin-resistant Staphylococcus aureus enhances pathogenicity in BALB/c mice. [PDF]
Liao F, Zou N, Shi Y, Gu W, Yuan B.
europepmc +1 more source
Correction to "Low Molecular Weight Fucoidan Inhibits Pulmonary Fibrosis In Vivo and In Vitro via Antioxidant Activity". [PDF]
europepmc +1 more source

