Results 51 to 60 of about 407,689 (298)

Biomechanical, ultrastructural, and electrophysiological characterization of the non-human primate experimental glaucoma model. [PDF]

, 2017
Laser-induced experimental glaucoma (ExGl) in non-human primates (NHPs) is a common animal model for ocular drug development. While many features of human hypertensive glaucoma are replicated in this model, structural and functional changes in the ...
Christian, Brian J, Eaton, J Seth, Gong, Haiyan, Miller, Paul E, Morgan, Joshua T, Murphy, Christopher J, Nork, T Michael, Raghunathan, VijayKrishna, Rasmussen, Carol A, Russell, Paul, Ver Hoeve, James N, Yang, Chen-Yuan Charlie   +11 more
core   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Deep Transfer Learning Methods for Colon Cancer Classification in Confocal Laser Microscopy Images

, 2019
Purpose: The gold standard for colorectal cancer metastases detection in the peritoneum is histological evaluation of a removed tissue sample. For feedback during interventions, real-time in-vivo imaging with confocal laser microscopy has been proposed ...
Bengs, Marcel, Drömann, Daniel, Ellebrecht, David B., Gessert, Nils, Keck, Tobias, Schlaefer, Alexander, Wittig, Lukas   +6 more
core   +1 more source

In Vivo Localization of Fas-Associated Death Domain Protein in the Nucleus and Cytoplasm of Normal Thyroid and Liver Cells [PDF]

, 2009
FADD (Fas-associated death domain) is the main death receptor adaptor molecule that transmits apoptotic signal. Recently, FADD protein was shown to be expressed both in the cytoplasm and nucleus of in vitro cell lines. In contrast to the cytoplasmic FADD,
Chiocchia, Gilles, Schmitt, Alain, Tourneur, Léa   +2 more
core   +5 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Meibomian Glands or Not? Identification of In Vivo and Ex Vivo Confocal Microscopy Features and Histological Correlates in the Eyelid Margin

Journal of Ophthalmology, 2020
Purpose. In vivo confocal laser scanning microscopy (CLSM) is an emerging diagnostic tool allowing fast and easy microscopic tissue examination. For the diagnostics of pathological eyelid margin lesions, the knowledge of the normal eyelid margin is ...
Yu-jing Wang, Min Ke
doaj   +1 more source

In vivo confocal microscopy of meibomian glands in glaucoma [PDF]

British Journal of Ophthalmology, 2012
To investigate, using laser scanning confocal microscopy (LSCM), the morphological changes of meibomian glands (MGs) in patients with glaucoma.A total of 80 patients who were glaucomatous were enrolled, and 20 healthy subjects were used as controls. After completing an Ocular Surface Disease Index (OSDI) questionnaire, all subjects underwent tear film ...
AGNIFILI, LUCA, FASANELLA, VINCENZO, C. Costagliola, CIABATTONI, CRISTINA, R. Mastropasqua, P. Frezzotti, MASTROPASQUA, Leonardo   +6 more
openaire   +7 more sources

Light-sheet microscopy: a tutorial [PDF]

, 2018
This paper is intended to give a comprehensive review of light-sheet (LS) microscopy from an optics perspective. As such, emphasis is placed on the advantages that LS microscope configurations present, given the degree of freedom gained by uncoupling the
Andilla, Jordi, Gualda, Emilio J., Loza-Alvarez, Pablo, Olarte, Omar E.   +3 more
core   +3 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

La bula de filtración por microscopía confocal in vivo Evaluation of the filtering bleb with in vivo confocal microscopy

Revista Cubana de Oftalmología, 2008
INTRODUCCIÓN: La aplicación de la microscopia confocal in vivo en la evaluación de la bula, después de la cirugía filtrante de glaucoma, permite relacionar las características morfológicas con la función de la bula de filtración y el tiempo de cirugía ...
Alexeide de la C. Castillo Pérez, Zaadia Pérez Parra, Ibraín Piloto Díaz, Liamet Fernández Argonés   +3 more
doaj