Results 261 to 270 of about 2,991,035 (302)

In Vivo Models of Rheumatoid Arthritis

2019
Rheumatoid arthritis (RA) models in mice induced by immunization enable the analyses of molecular mechanism involved in disease development, progression, and resolution of inflammation. Here, we describe three different models mimicking clinic symptoms of human rheumatoid arthritis, which could be transferable to any genetically modified mouse. We will
Bettina, Grötsch, Aline, Bozec, Georg, Schett   +2 more
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An experimental model of in vivo fibrinolysis

Thrombosis Research, 1976
Abstract An experimental model of in vivo fibrinolysis was devised for estimation of in vivo fibrinolytic activity in experimental animals (rat, rabbit and dog). The method consists of intravenous injection of homogenized human fibrin into an animal and subsequent immunological determination of fibrin degradation products (FDP) in a small
Y, Sasaki, T, Morita
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In Vivo Models of Mechanical Loading

2019
The skeleton fulfils its mechanical functions through structural organization and material properties of individual bones. It is stated that both cortical and trabecular morphology and mass can be (re)modelled in response to changes in mechanical strains engendered by load-bearing.
Javaheri, Behzad, Bravenboer, Nathalie, Bakker, Astrid D., van der Veen, Albert, de Souza, Roberto Lopes, Saxon, Leanne, Pitsillides, Andrew A.   +6 more
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In Vivo Models for Inflammatory Arthritis

2018
In vivo mouse models of inflammatory arthritis are extensively used to investigate pathogenic mechanisms governing inflammation-driven joint damage. Two commonly utilized models include collagen-induced arthritis (CIA) and methylated bovine serum albumin (mBSA) antigen-induced arthritis (AIA).
Jones, Gareth, Hill, David, Sime, Katie, Williams, Anwen   +3 more
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In vivo models of proliferative vitreoretinopathy

Nature Protocols, 2007
We outline current in vitro and in vivo models for experimental proliferative vitreoretinopathy (PVR) and provide a detailed protocol of our standardized in vivo PVR model. PVR is the leading cause of failed surgical procedures for the correction of rhegmatogenous retinal detachment.
Rajat N, Agrawal, Shikun, He, Christine, Spee, Jing Z, Cui, Stephen J, Ryan, David R, Hinton   +5 more
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In Vivo Modeling for Glucose Homeostasis

IEEE Transactions on Biomedical Engineering, 1975
A model for the glucose-insulin control system has been developed. The primary controllers in this model are the pancreas and liver. These subsystems operate within the metabolic environment to maintain normal glucose levels. The prime control variables for each subsystem, as well as for systemic glucose utilization, are the plasma glucose and insulin ...
S M, Finkelstein, M A, Bleicher, S, Batthany, J, Tiefenbrun   +3 more
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Xenograft as In Vivo Experimental Model

2017
The identification of experimental models that recapitulate human cancers designed to predict patient clinical response to therapies is a major break in oncology. Cancer stem cells (CSCs) represent a small tumor cell population responsible for drug resistance, where their effective killing may lead to identifying better treatment options.
Manuela, Porru, Luca, Pompili, Carla, Caruso, Carlo, Leonetti   +3 more
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In vivo models in the study of osteopenias.

European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, 1991
A better insight into bone pathophysiology is required for a full understanding of the mechanisms leading to bone loss in humans. Animal models of bone disease appear to be the most valuable for this purpose. Certain differences in bone metabolism exist between various species.
Češnjaj, Mirjana, Stavljenić, Ana, Vukičević, Slobodan   +2 more
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In Vivo Models of Muscle Angiogenesis

2016
Angiogenesis is an important determinant of tissue function, from delivery of oxygen and other substrates to removal of waste products, in health and disease (e.g., adaptive or pathological remodelling). The phenotype and functional responses of endothelial cells are conditioned by systemic humoral signals and local environmental factors, including the
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In Vivo Models of Developmental Toxicology

2012
The founding principles of teratology/developmental toxicology state that a developmental toxicants cause dysmorphogenesis when conceptuses are exposed at a sufficient dosage during a sensitive period of development in a sensitive species. While in vitro approaches in developmental toxicology can provide a means to assess the potency of toxicants ...
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