Results 51 to 60 of about 189,682 (288)
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Moving into View: Enacting Virtual Reality
MediaTropes, 2016 How do we perceive virtual reality? This simple question takes the reader on a journey into the physiology of perception, following cybernetic models that regard spatial perception as an activity that presupposes bodily motion.
Lasse Scherffig
doaj
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
¡Inacción! : Comentarios sobre los cuatro libros de G. Agamben
Cuadernos de Proyectos Arquitectónicos, 2015 ResumenUn intento por no comentar un libro, sino varios, una propuesta de ediciónque rastrea la presencia de la inacción en la obra de Agamben. Inacción que permanece velada por la fuerza del pensamiento genuinamente político de su autor, al que está ...
Andrés Carretero
doaj
The behaviour of the MPC: Gradualism, inaction and individual voting patterns [PDF]
We evaluate the degree of gradualism and inaction in UK monetary policy over the Monetary Policy Committee (MPC) period (1997-2007) at the quarterly and the monthly frequency. After accounting for misspecification in standard Taylor rules, we find little
Groth, Charlotta, Wheeler, Tracy
core
Estimation of a dynamic discrete choice model of irreversible investment [PDF]
, 2001 In this paper we propose and estimate a dynamic structural model of fixed capital investment at the firm level. Our dataset consists of an unbalanced panel of Spanish manufacturing firms. Two important features are present in this dataset.
Sánchez Mangas, Rocío
core +2 more sources
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Press Start, 2020 This paper represents an initiatory investigation into moments of inaction in games. Two types of inaction are defined and discussed: stasis, which is inaction brought on by or through a game’s mechanics, and stillness, which is brought on by or through ...
Rainforest Scully-Blaker
doaj