Results 161 to 170 of about 132,304 (290)

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Safety, immunogenicity, and efficacy of an mRNA COVID-19 vaccine (RQ3013) given as the fourth booster following three doses of inactivated vaccines: a double-blinded, randomised, controlled, phase 3b trial. [PDF]

EClinicalMedicine, 2023
Liu X, Sun Z, Wang Z, Chen J, Wu Q, Zheng Y, Yang X, Mo L, Yan X, Li W, Zou Y, Song H, Qian F, Lu J, Zhou H, Wang Y, Xiang Z, Yu H, Lin J, Yuan L, Zheng Y.   +20 more
europepmc   +1 more source

Nasal Delivery of mRNA Using Thermoresponsive Gellable Aqueous Biphasic Systems

Small, EarlyView.
Nasal delivery of mRNA using gellable aqueous biphasic systems (ABS) represents a noninvasive alternative while reducing the need for trained professionals and cold chain storage. Composed of gelatin, PEG, and water, these thermoresponsive hydrogels ensure controlled mRNA delivery and prolonged retention at the nasal mucosa, improving transfection ...
Bojan Kopilovic, Nabila Laroui, João A.P. Coutinho, Chantal Pichon, Mara G. Freire   +4 more
wiley   +1 more source

Immunogenicity profiling and distinct immune response in liver transplant recipients vaccinated with SARS-CoV-2 inactivated vaccines. [PDF]

Front Immunol, 2022
Duan B, Zhang G, Wang W, Yin J, Liu M, Zhang J, Chen D, Ouyang Y, Li G.   +8 more
europepmc   +1 more source

Unravelling Electronic Structure and Molecular Vibrations of Proteins in Virus Using Novel Correlated Plasmon‐Enhanced Raman Spectroscopy With Machine Learning

Small, EarlyView.
A novel, non‐destructive, stable, direct technique, named correlated plasmon‐enhanced Raman spectroscopy (CP‐ERS), which is based on a newly‐developed highly oriented single crystalline gold quantum dots (HOSG‐QDs) chip, is developed to measure and quantify molecular vibrations and electronic structure of analytes.
Vashu Kamboj, Shermine Ho, Fakhriedzwan Idris, Donald Heng Rong Ting, Khadijah Bte Kamsari Sanuh, Sylvie Alonso, Eng Soon Tok, Andrivo Rusydi   +7 more
wiley   +1 more source

Virulence genes contributing to Aeromonas veronii pathogenicity in Nile tilapia (Oreochromis niloticus): approaching the development of live and inactivated vaccines. [PDF]

Aquac Int, 2023
Youssef HA, Ayoub HF, Soror EI, Matter AF.   +3 more
europepmc   +1 more source

Engineering Biomimetic Nanoparticle Performance Through Fabrication Method Selection: Turbulent Jet Mixing, Microfluidics, and Extrusion

Small Methods, EarlyView.
Biomimetic nanoparticles (BNPs) combine liposomal biocompatibility with cell‐mimicking functions for targeted delivery. This study compares turbulent jet mixing, microfluidic mixing, and extrusion for BNP fabrication. Characterization, proteomics, and in vitro assays show that turbulent jet and microfluidic mixing produce stable, protein‐enriched ...
Ilana Elizarov, Rawan Mhajne, Ofri Vizenblit, Assaf Zinger   +3 more
wiley   +1 more source

Inactivated Vaccines Against SARS-CoV-2: Neutralizing Antibody Titers in Vaccine Recipients. [PDF]

Front Microbiol, 2022
Zhang H, Jia Y, Ji Y, Cong X, Liu Y, Yang R, Kong X, Shi Y, Zhu L, Wang Z, Wang W, Fei R, Liu F, Lu F, Chen H, Rao H.   +15 more
europepmc   +1 more source

Selective Wettability–Driven Evaporation‐Enhanced Redox Cycling for Robust and Ultrasensitive Detection of Viral Particles

Small Methods, EarlyView.
ABSTRACT Timely detection of viral infections, particularly in settings outside centralized laboratories, is essential for controlling outbreaks. Small electrochemical biosensors are appealing because they are fast, require microliter sample volumes, and can be integrated into portable devices.
Pouya Soltan Khamsi, Shubhada K Chothe, Suresh V Kuchipudi, Aida Ebrahimi   +3 more
wiley   +1 more source

Antiviral Inactivated Vaccines: Looking to the Past to Face the Future-A Narrative Review. [PDF]

Vaccines (Basel)
Guedes-da-Silva FH, Roncaglia-Pereira VA, Torres S, García MCE, Viana KF, Silva JL, Oliveira AC, Gomes AMO.   +7 more
europepmc   +1 more source