Inactivation of metabolic genes causes short- and long-range dys-regulation in Escherichia coli metabolic network. [PDF]
PLoS ONE, 2013 The metabolic network in E. coli can be severely affected by the inactivation of metabolic genes that are required to catabolize a nutrient (D-galactose).
Dinesh Kumar Barupal +3 more
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Functional Inactivation of Mast Cells Enhances Subcutaneous Adipose Tissue Browning in Mice
Cell Reports, 2019 Summary: Adipose tissue browning and systemic energy expenditure provide a defense mechanism against obesity and associated metabolic diseases. In high-cholesterol Western diet-fed mice, mast cell (MC) inactivation ameliorates obesity and insulin ...
Xian Zhang +10 more
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Nature Communications, 2019 Insulin/IGF-1 signalling plays an important role in the regulation of metabolism and ageing. Here the authors show that inactivation of the pathway component PI3K p110α in the adipose tissue of mice produces a beneficial metabolic effect by enhancing β ...
Caroline Araiz +8 more
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BMC Genomics, 2010 Background Genome reduction is a common evolutionary process in symbiotic and pathogenic bacteria. This process has been extensively characterized in bacterial endosymbionts of insects, where primary mutualistic bacteria represent the most extreme cases ...
Moya Andrés +3 more
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Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism [PDF]
Nature Communications, 2021 Histone acetylations are important epigenetic marks for transcriptional activation and respond to metabolic changes. Here the authors develop a lifespan screen and show that inactivation of the histone deacetylase complex activates longevity and protects
Ruofan Yu +12 more
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Selective Inactivation Strategies for Vegetable Raw Materials: Regulating Microbial Communities to Ensure the Safety and Quality of Fermented Vegetables [PDF]
FoodsFermented vegetables, which are valued for their distinctive organoleptic properties and nutritional profile, are susceptible to quality deterioration during processing and storage because microorganisms inhabit vegetable raw materials.
Lin Zhu +7 more
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Long‐term p110α PI3K inactivation exerts a beneficial effect on metabolism
EMBO Molecular Medicine, 2013 The insulin/insulin‐like growth factor‐1 signalling (IIS) pathway regulates cellular and organismal metabolism and controls the rate of aging. Gain‐of‐function mutations in p110α, the principal mammalian IIS‐responsive isoform of PI 3‐kinase (PI3K ...
Lazaros C. Foukas +7 more
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Cyclopropylamine inactivation of cytochromes P450: Role of metabolic intermediate complexes [PDF]
Archives of Biochemistry and Biophysics, 2005 The inactivation of cytochrome P450 enzymes by cyclopropylamines has been attributed to a mechanism involving initial one-electron oxidation at nitrogen followed by scission of the cyclopropane ring leading to covalent modification of the enzyme. Herein, we report that in liver microsomes N-cyclopropylbenzylamine (1) and related compounds inactivate ...
Cerny, Matthew A., Hanzlik, Robert P.
openaire +4 more sources
Delta-like ligand 4 mediated myeloid-derived suppressor cell metabolic reprogramming promotes neoadjuvant therapy resistance in titin-inactivated triple-negative breast cancer [PDF]
Molecular BiomedicineTriple-negative breast cancer (TNBC) is characterized by complex genomic background and treatment resistance. We first defined “Titin (TTN) inactivation”, a state of TTN expression deficiency or mutation, affecting tumor progression.
Yanfang Yang +10 more
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Frontiers in Veterinary Science, 2022 In the recent years, safety concerns regarding the administration of probiotics led to an increased interest in developing inactivated probiotics, also called “paraprobiotics”.
Luca Porfiri +6 more
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