Results 11 to 20 of about 163,771 (263)

Metabolism and inactivation of neurotransmitters in nematodes

Parasitology, 1996
SUMMARYThe nematode nervous system employs many of the same neurotransmitters as are found in higher animals. The inactivation of neurotransmitters is absolutely essential for the correct functioning of the nervous system, In this article we discuss the various mechanisms used generally in animal nervous systems for synaptic inactivation of ...
R E, Isaac, D, MacGregor, D, Coates
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Inactivation of Insulin by Intermediary Fat Metabolism Products [PDF]

Nature, 1946
IT has been recorded by several workers that insulin, though effective in most diabetics in lowering the blood-sugar level to normal, in a small fraction of cases either does not react at all or very high doses are required for beneficial results. Rosenthal1 observed that one of his patients showed no relief in hyperglycaemia even by daily injections ...
M C, NATH, H D, BRAHMACHARI
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Functional Inactivation of Mast Cells Enhances Subcutaneous Adipose Tissue Browning in Mice

Cell Reports, 2019
Summary: Adipose tissue browning and systemic energy expenditure provide a defense mechanism against obesity and associated metabolic diseases. In high-cholesterol Western diet-fed mice, mast cell (MC) inactivation ameliorates obesity and insulin ...
Xian Zhang, Xin Wang, Hao Yin, Lei Zhang, Airong Feng, Qiu-Xia Zhang, Yan Lin, Bin Bao, Laura L. Hernandez, Guo-Ping Shi, Jian Liu   +10 more
doaj   +1 more source

Long‐term p110α PI3K inactivation exerts a beneficial effect on metabolism

EMBO Molecular Medicine, 2013
The insulin/insulin‐like growth factor‐1 signalling (IIS) pathway regulates cellular and organismal metabolism and controls the rate of aging. Gain‐of‐function mutations in p110α, the principal mammalian IIS‐responsive isoform of PI 3‐kinase (PI3K ...
Lazaros C. Foukas, Benoit Bilanges, Lucia Bettedi, Wayne Pearce, Khaled Ali, Sara Sancho, Dominic J. Withers, Bart Vanhaesebroeck   +7 more
doaj   +1 more source

Systemic deletion of Atp7b modifies the hepatocytes’ response to copper overload in the mouse models of Wilson disease

Scientific Reports, 2021
Wilson disease (WD) is caused by inactivation of the copper transporter Atp7b and copper overload in tissues. Mice with Atp7b deleted either globally (systemic inactivation) or only in hepatocyte recapitulate various aspects of human disease.
Abigael Muchenditsi, C. Conover Talbot, Aline Gottlieb, Haojun Yang, Byunghak Kang, Tatiana Boronina, Robert Cole, Li Wang, Som Dev, James P. Hamilton, Svetlana Lutsenko   +10 more
doaj   +1 more source

Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism

Nature Communications, 2021
Histone acetylations are important epigenetic marks for transcriptional activation and respond to metabolic changes. Here the authors develop a lifespan screen and show that inactivation of the histone deacetylase complex activates longevity and protects
Ruofan Yu, Xiaohua Cao, Luyang Sun, Jun-yi Zhu, Brian M Wasko, Wei Liu, Emeline Crutcher, Haiying Liu, Myeong Chan Jo, Lidong Qin, Matt Kaeberlein, Zhe Han, Weiwei Dang   +12 more
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Effects of tendamistate (alpha‐amylase inactivator) on starch metabolism. [PDF]

British Journal of Clinical Pharmacology, 1983
Abstract 1 Tendamistate (Hoe 467) reduces gastrointestinal absorption of starch by inactivating α-amylase. 2 Two trials were performed to investigate the influence of timing and mode of administration of tendamistate, relative to starch intake, on the pharmacodynamics of the drug. (i) In the first trial 400 mg enteric coated capsules, 400 mg non-
B H, Meyer, F O, Müller, B K, Clur, H G, Grigoleit   +3 more
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PAS Kinase: A Nutrient and Energy Sensor “Master Key” in the Response to Fasting/Feeding Conditions

Frontiers in Endocrinology, 2020
The protein kinase with PAS domains (PASK) is a nutrient and energy sensor located in the cells of multiple organs. Many of the recent findings for understanding PASK functions in mammals have been reported in studies involving PASK-deficient mice.
Verónica Hurtado-Carneiro, Verónica Hurtado-Carneiro, Ana Pérez-García, Elvira Alvarez, Carmen Sanz   +4 more
doaj   +1 more source

Inactivation of metabolic genes causes short- and long-range dys-regulation in Escherichia coli metabolic network. [PDF]

PLoS ONE, 2013
The metabolic network in E. coli can be severely affected by the inactivation of metabolic genes that are required to catabolize a nutrient (D-galactose).
Dinesh Kumar Barupal, Sang Jun Lee, Edward D Karoly, Sankar Adhya   +3 more
doaj   +1 more source

Promotion of healthy adipose tissue remodeling ameliorates muscle inflammation in a mouse model of sarcopenic obesity

Frontiers in Nutrition, 2023
A large subset of elders is classified as having sarcopenic obesity, a prevalence of obesity in combination with sarcopenia which places an aging population at the risk of adverse health consequences from both conditions.
Yunlin Ge, Siqi Li, Siqi Li, Tao Yao, Yuexiao Tang, Yuexiao Tang, Qiangyou Wan, Xiaoli Zhang, Jing Zhao, Mingliang Zhang, Mengle Shao, Lijun Wang, Lijun Wang, Ying Wu, Ying Wu, Ying Wu   +15 more
doaj   +1 more source