Results 1 to 10 of about 163,771 (263)

Comprehensive characterisation of IAA inactivation pathways reveals the impact of glycosylation on auxin metabolism and plant development in Arabidopsis [PDF]

Communications Biology
Alongside biosynthesis and transport, inactivation regulates indole-3-acetic acid (IAA) concentration, a compound with numerous functions in plant development.
Rubén Casanova-Sáez, Aleš Pěnčík, Federica Brunoni, Anita Ament, Pavel Hladík, Asta Žukauskaitė, Jan Šimura, Ute Voß, Ondřej Novák, Malcolm Bennett, Karin Ljung, Eduardo Mateo-Bonmatí   +11 more
doaj   +2 more sources

Impact of inactivation methods on biosafety and antigen reactivity of Brucella melitensis from the perspective of Astral-DIA proteomics based on antibody immunoprecipitation mass spectrometry. [PDF]

PLoS Neglected Tropical Diseases
Effective Brucella inactivation is essential for safe vaccine development, diagnostics, and sample handling, particularly in resource-limited regions without high-level biosafety facilities.
Yijian Liu, Jiazhen Ge, Guodong Song, Pengcheng Gao, Mengzhu Qi, Wenhao Wang, Yingying Xie, Ziqing Wang, Renge Li, Yuefeng Chu, Fuying Zheng   +10 more
doaj   +2 more sources

Cold atmospheric plasma degrades methylene blue and shifts bacterial inactivation during photodynamic therapy [PDF]

Scientific Reports
Photodynamic therapy (PDT) and cold atmospheric plasma can inactivate bacteria via oxidative stress. Here we examined their combined action against Staphylococcus aureus (S. aureus) using methylene blue (MB)-mediated PDT with a red organic light-emitting
Ki Ho Baek, Joo Young Park, Ye-bin Yoon, Juyeon Choi, Sunghoon Jung, Yeong-Jin Choi, Min-Ju Choi, Hae In Yong, Seunghun Lee   +8 more
doaj   +2 more sources

Irradiated Non-replicative Lactic Acid Bacteria Preserve Metabolic Activity While Exhibiting Diverse Immune Modulation

Frontiers in Veterinary Science, 2022
In the recent years, safety concerns regarding the administration of probiotics led to an increased interest in developing inactivated probiotics, also called “paraprobiotics”.
Luca Porfiri, Johanna Burtscher, Richard T. Kangethe, Doris Verhovsek, Giovanni Cattoli, Konrad J. Domig, Viskam Wijewardana   +6 more
doaj   +1 more source

Metabolic status differentiates Trp53inp2 function in pressure-overload induced heart failure

Frontiers in Cardiovascular Medicine, 2023
Cardiometabolic disorders encompass a broad range of cardiovascular complications associated with metabolic dysfunction. These conditions have an increasing share in the health burden worldwide due to worsening endemic of hypertension, obesity, and ...
Jianfang Liu, Tian Liu, Shuxun (Vincent) Ren, Cansheng Zhu, Eyad Bouso, Samir Mamlouk, Christoph D. Rau, Yibin Wang, Chen Gao   +8 more
doaj   +1 more source

Hyperactivated Wnt signaling induces synthetic lethal interaction with Rb inactivation by elevating TORC1 activities. [PDF]

PLoS Genetics, 2014
Inactivation of the Rb tumor suppressor can lead to increased cell proliferation or cell death depending on specific cellular context. Therefore, identification of the interacting pathways that modulate the effect of Rb loss will provide novel insights ...
Tianyi Zhang, Yang Liao, Fu-Ning Hsu, Robin Zhang, Jennifer S Searle, Xun Pei, Xuan Li, Hyung Don Ryoo, Jun-Yuan Ji, Wei Du   +9 more
doaj   +1 more source

Proteomics-based analysis of the stress response of Bacillus cereus spores under ultrasound and electrolyzed water treatment

Ultrasonics Sonochemistry, 2023
Ultrasound is a green nonthermal technology with promising applications in microbial inactivation. Electrolyzed water has been investigated and found to have a synergistic inactivation effect of ultrasound on spores.
Zixuan Jia, Jianwei Zhou, Jingzeng Han, Donghong Liu, Ruiling Lv   +4 more
doaj   +1 more source

Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis

mBio, 2023
Nicotinamide adenine dinucleotide (NAD) and its phosphorylated derivative (NADP) are essential cofactors that participate in hundreds of biochemical reactions and have emerged as therapeutic targets in cancer, metabolic disorders, neurodegenerative ...
Ritu Sharma, Travis E. Hartman, Tiago Beites, Jee-Hyun Kim, Hyungjin Eoh, Curtis A. Engelhart, Linnan Zhu, Daniel J. Wilson, Courtney C. Aldrich, Sabine Ehrt, Kyu Young Rhee, Dirk Schnappinger   +11 more
doaj   +1 more source

Derivation of healthy hepatocyte-like cells from a female patient with ornithine transcarbamylase deficiency through X-inactivation selection

Scientific Reports, 2022
Autologous cell replacement therapy for inherited metabolic disorders requires the correction of the underlying genetic mutation in patient’s cells. An unexplored alternative for females affected from X-linked diseases is the clonal selection of cells ...
Ramon Santamaria, Maria Ballester, Guillem Garcia-Llorens, Francisco Martinez, Marina Blazquez, Carmen Ribes-Koninckx, Jose V. Castell, Torsten Wuestefeld, Roque Bort   +8 more
doaj   +1 more source

Mutant TDP-43 deregulates AMPK activation by PP2A in ALS models. [PDF]

PLoS ONE, 2014
Bioenergetic abnormalities and metabolic dysfunction occur in amyotrophic lateral sclerosis (ALS) patients and genetic mouse models. However, whether metabolic dysfunction occurs early in ALS pathophysiology linked to different ALS genes remains unclear.
Nirma D Perera, Rebecca K Sheean, John W Scott, Bruce E Kemp, Malcolm K Horne, Bradley J Turner   +5 more
doaj   +3 more sources