Results 11 to 20 of about 2,032,731 (300)

Metabolic status differentiates Trp53inp2 function in pressure-overload induced heart failure

Frontiers in Cardiovascular Medicine, 2023
Cardiometabolic disorders encompass a broad range of cardiovascular complications associated with metabolic dysfunction. These conditions have an increasing share in the health burden worldwide due to worsening endemic of hypertension, obesity, and ...
Jianfang Liu, Tian Liu, Shuxun (Vincent) Ren, Cansheng Zhu, Eyad Bouso, Samir Mamlouk, Christoph D. Rau, Yibin Wang, Chen Gao   +8 more
doaj   +1 more source

Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1

Science, 2023
Adenosine monophosphate–activated protein kinase (AMPK) activity is stimulated to promote metabolic adaptation upon energy stress. However, sustained metabolic stress may cause cell death.
Tao Zhang, Daichao Xu, Elijah Trefts, Mingming Lv, H. Inuzuka, G. Song, Min Liu, Jianlin Lu, Jianping Liu, C. Chu, Min Wang, Huibing Wang, Huyan Meng, Hui Liu, Yuan Zhuang, Xingxing Xie, Fabin Dang, Dongxian Guan, Yuqin Men, Shuwen Jiang, Cong Jiang, Xiaoming Dai, Jing Liu, Zhen Wang, Peiqiang Yan, Jingchao Wang, Zhenbo Tu, Mrigya Babuta, Emily C. Erickson, Alissandra L. Hillis, Christian C. Dibble, J. Asara, Gyongyi Szabo, P. Sicinski, Ji Miao, Yu-Ru Lee, L. Pan, R. Shaw, Junying Yuan, Wenyi Wei   +39 more
semanticscholar   +1 more source

The Mechanism-Based Inactivation of CYP3A4 by Ritonavir: What Mechanism?

International Journal of Molecular Sciences, 2022
Ritonavir is the most potent cytochrome P450 (CYP) 3A4 inhibitor in clinical use and is often applied as a booster for drugs with low oral bioavailability due to CYP3A4-mediated biotransformation, as in the treatment of HIV (e.g., lopinavir/ritonavir ...
N. Loos, J. Beijnen, A. Schinkel
semanticscholar   +1 more source

Hyperactivated Wnt signaling induces synthetic lethal interaction with Rb inactivation by elevating TORC1 activities. [PDF]

PLoS Genetics, 2014
Inactivation of the Rb tumor suppressor can lead to increased cell proliferation or cell death depending on specific cellular context. Therefore, identification of the interacting pathways that modulate the effect of Rb loss will provide novel insights ...
Tianyi Zhang, Yang Liao, Fu-Ning Hsu, Robin Zhang, Jennifer S Searle, Xun Pei, Xuan Li, Hyung Don Ryoo, Jun-Yuan Ji, Wei Du   +9 more
doaj   +1 more source

Proteomics-based analysis of the stress response of Bacillus cereus spores under ultrasound and electrolyzed water treatment

Ultrasonics Sonochemistry, 2023
Ultrasound is a green nonthermal technology with promising applications in microbial inactivation. Electrolyzed water has been investigated and found to have a synergistic inactivation effect of ultrasound on spores.
Zixuan Jia, Jianwei Zhou, Jingzeng Han, Donghong Liu, Ruiling Lv   +4 more
doaj   +1 more source

Metabolic reprogramming in renal cancer: Events of a metabolic disease.

Biochimica et biophysica acta. Reviews on cancer, 2021
Recent studies have established that tumors can reprogram the pathways involved in nutrient uptake and metabolism to withstand the altered biosynthetic, bioenergetics and redox requirements of cancer cells.
S. Chakraborty, Murugabaskar Balan, Akash Sabarwal, T. Choueiri, S. Pal   +4 more
semanticscholar   +1 more source

Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis

mBio, 2023
Nicotinamide adenine dinucleotide (NAD) and its phosphorylated derivative (NADP) are essential cofactors that participate in hundreds of biochemical reactions and have emerged as therapeutic targets in cancer, metabolic disorders, neurodegenerative ...
Ritu Sharma, Travis E. Hartman, Tiago Beites, Jee-Hyun Kim, Hyungjin Eoh, Curtis A. Engelhart, Linnan Zhu, Daniel J. Wilson, Courtney C. Aldrich, Sabine Ehrt, Kyu Young Rhee, Dirk Schnappinger   +11 more
doaj   +1 more source

Metabolic regulation of systemic acquired resistance.

Current opinion in plant biology, 2021
Plants achieve an optimal balance between growth and defense by a fine-tuned biosynthesis and metabolic inactivation of immune-stimulating small molecules.
J. Zeier
semanticscholar   +1 more source

Rapid Determination of Antimicrobial Susceptibility by Stimulated Raman Scattering Imaging of D2O Metabolic Incorporation in a Single Bacterium [PDF]

Advancement of science, 2020
Rapid antimicrobial susceptibility testing (AST) is urgently needed for treating infections with appropriate antibiotics and slowing down the emergence of antibiotic‐resistant bacteria.
Meng Zhang, Weili Hong, Nader S. Abutaleb, Junjie Li, Pu-Ting Dong, Cheng Zong, Pu Wang, M. Seleem, Ji‐Xin Cheng   +8 more
semanticscholar   +1 more source

Derivation of healthy hepatocyte-like cells from a female patient with ornithine transcarbamylase deficiency through X-inactivation selection

Scientific Reports, 2022
Autologous cell replacement therapy for inherited metabolic disorders requires the correction of the underlying genetic mutation in patient’s cells. An unexplored alternative for females affected from X-linked diseases is the clonal selection of cells ...
Ramon Santamaria, Maria Ballester, Guillem Garcia-Llorens, Francisco Martinez, Marina Blazquez, Carmen Ribes-Koninckx, Jose V. Castell, Torsten Wuestefeld, Roque Bort   +8 more
doaj   +1 more source