Results 41 to 50 of about 2,032,731 (300)

Inactivation of the Mitochondrial Carrier SLC25A25 (ATP-Mg2+/Pi Transporter) Reduces Physical Endurance and Metabolic Efficiency in Mice*

Journal of Biological Chemistry, 2011
An ATP-Mg2+/Pi inner mitochondrial membrane solute transporter (SLC25A25), which is induced during adaptation to cold stress in the skeletal muscle of mice with defective UCP1/brown adipose tissue thermogenesis, has been evaluated for its role in ...
R. Anunciado-Koza, Jingying Zhang, J. Ukropec, S. Bajpeyi, R. Koza, R. Rogers, W. Cefalu, R. Mynatt, L. Kozak   +8 more
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The Metabolic Landscape of Lung Cancer: New Insights in a Disturbed Glucose Metabolism

Frontiers in Oncology, 2019
Metabolism encompasses the biochemical processes that allow healthy cells to keep energy, redox balance and building blocks required for cell development, survival, and proliferation steady.
K. Vanhove, Geert-Jan Graulus, L. Mesotten, M. Thomeer, E. Derveaux, J. Noben, W. Guedens, P. Adriaensens   +7 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Endothelial H2S-AMPK dysfunction upregulates the angiocrine factor PAI-1 and contributes to lung fibrosis

Redox Biology
Dysfunction of the vascular angiocrine system is critically involved in regenerative defects and fibrosis of injured organs. Previous studies have identified various angiocrine factors and found that risk factors such as aging and metabolic disorders can
Xiangqi Chen, Han Wang, Chuan Wu, Xiaoyan Li, Xiaojuan Huang, Yafeng Ren, Qiang Pu, Zhongwei Cao, Xiaoqiang Tang, Bi-Sen Ding   +9 more
doaj   +1 more source

Metabolic inactivation of amatoxins by nontoxicAmanita species

Experimental Mycology, 1984
Abstract The capacities of developing Amanita carpophores to translocate and metabolically alter amatoxins were examined. The tritium-labeled derivative [ 3 H]6′- O -methyl-dehydroxymethyl-α-amanitin was administered either alone or in solution with α-amanitin or 6′- O -methyl-α-amanitin to the volvae or bulbs of immature carpophores of several ...
Department of Microbiology and Cell Science, University of Florida, Gainesville, Florida 32611 USA ( host institution ), Romeo, Tony, Preston, James F.   +2 more
openaire   +2 more sources

Metabolic and oncogenic adaptations to pyruvate dehydrogenase inactivation in fibroblasts [PDF]

Journal of Biological Chemistry, 2019
Eukaryotic cell metabolism consists of processes that generate available energy, such as glycolysis, the tricarboxylic acid (TCA) cycle, and oxidative phosphorylation (Oxphos), and those that consume it, including macromolecular synthesis, the maintenance of ionic gradients, and cellular detoxification. By converting pyruvate to acetyl-CoA (AcCoA), the
Huabo, Wang, Jie, Lu, Sucheta, Kulkarni, Weiqi, Zhang, Joanna E, Gorka, Jordan A, Mandel, Eric S, Goetzman, Edward V, Prochownik   +7 more
openaire   +2 more sources

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

Journal of Cell Biology, 2009
mTor, acting mainly via mTORC1, controls dystrophin transcription in a raptor- and rictor-independent mechanism.
V. Risson, L. Mazelin, M. Roceri, H. Sanchez, V. Moncollin, C. Corneloup, Hélène Richard-Bulteau, A. Vignaud, D. Baas, A. Defour, D. Freyssenet, J. Tanti, Yannick Le-Marchand-Brustel, B. Ferrier, A. Conjard-Duplany, Klaas Romanino, S. Bauché, D. Hantaï, Matthias Mueller, S. Kozma, G. Thomas, M. Rüegg, A. Ferry, M. Pende, X. Bigard, N. Koulmann, L. Schaeffer, Yann-Gaël Gangloff   +27 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source