Results 51 to 60 of about 163,771 (263)

Modulation of Escherichia coli Translation by the Specific Inactivation of tRNAGly Under Oxidative Stress

Frontiers in Genetics, 2020
Bacterial oxidative stress responses are generally controlled by transcription factors that modulate the synthesis of RNAs with the aid of some sRNAs that control the stability, and in some cases the translation, of specific mRNAs.
Lorenzo Eugenio Leiva, Andrea Pincheira, Sara Elgamal, Sandra D. Kienast, Sandra D. Kienast, Sandra D. Kienast, Verónica Bravo, Johannes Leufken, Johannes Leufken, Johannes Leufken, Daniela Gutiérrez, Sebastian A. Leidel, Sebastian A. Leidel, Sebastian A. Leidel, Michael Ibba, Assaf Katz   +15 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Regulation of antibiotic persistence and pathogenesis in Acinetobacter baumannii by glutamate and histidine metabolic pathways

BMC Microbiology
Background Metabolite production is essential for the proliferation and environmental adaptation of all living organisms. In pathogenic bacteria, metabolite exchange during host infection can regulate their physiology and virulence.
Ho Seok Sim, Yong-Kook Kwon, Hokyung Song, Geum-Sook Hwang, Jinki Yeom   +4 more
doaj   +1 more source

Consequences of phosphoenolpyruvate:sugar phosphotranferase system and pyruvate kinase isozymes inactivation in central carbon metabolism flux distribution in Escherichia coli

Microbial Cell Factories, 2012
Background In Escherichia coli phosphoenolpyruvate (PEP) is a key central metabolism intermediate that participates in glucose transport, as precursor in several biosynthetic pathways and it is involved in allosteric regulation of glycolytic enzymes.
Meza Eugenio, Becker Judith, Bolivar Francisco, Gosset Guillermo, Wittmann Christoph   +4 more
doaj   +1 more source

Single or combined ablation of peripheral serotonin and p21 limit adipose tissue expansion and metabolic alterations in early adulthood in mice fed a normocaloric diet.

PLoS ONE, 2021
Identifying the fundamental molecular factors that drive weight gain even in the absence of hypercaloric food intake, is crucial to enable development of novel treatments for the global pandemic of obesity.
Enrica Saponara, Rong Chen, Theresia Reding, Richard Zuellig, Darren C Henstridge, Rolf Graf, Sabrina Sonda   +6 more
doaj   +1 more source

Cyclopropylamine inactivation of cytochromes P450: Role of metabolic intermediate complexes [PDF]

Archives of Biochemistry and Biophysics, 2005
The inactivation of cytochrome P450 enzymes by cyclopropylamines has been attributed to a mechanism involving initial one-electron oxidation at nitrogen followed by scission of the cyclopropane ring leading to covalent modification of the enzyme. Herein, we report that in liver microsomes N-cyclopropylbenzylamine (1) and related compounds inactivate ...
Cerny, Matthew A., Hanzlik, Robert P.
openaire   +3 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Transient Inactivation of Shell Part of Nucleus Accumbens Inhibits and Exacerbates Stress-Induced Metabolic Alterations in Wistar Rats

Basic and Clinical Neuroscience, 2017
Introduction: The role of different parts of the extended amygdala in metabolic signs of stress is not well understood. In the present study, we decided to evaluate the impact of the shell part of nucleus accumbens (NAc) on metabolic disturbance induced ...
Mina Ranjbaran, Hassan Aghaei, Vahdat Hajihoseinlou, Hedayat Sahraei, Katayoon Ranjbaran   +4 more
doaj  

Proteomic Analysis of Listeria monocytogenes Subjected to Pulsed Magnetic Field

Foods
As one of the non-thermal technologies, the pulsed magnetic field (PMF) has increasingly attracted attention for its application in food microbial inactivation.
Di Chen, Jingya Qian, Shuhao Huo, Feng Wang, Haile Ma, Shan Liu   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source