Results 161 to 170 of about 993,849 (289)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

The Excelsatoxin A-Receptor TMEM233 Modulates Nav1.8. [PDF]

FASEB J
Oprita G, Meyer MJA, Rudolf D, Pombeiro Stein ICA, Deuis JR, Tran HNT, Durek T, Tabea K, Sina J, Waxman SG, Dib-Hajj SD, Babes A, Vetter I, Leffler A.   +13 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Thalamic reticular neurons provide cell type-specific modulation of sound processing in the auditory thalamus. [PDF]

PLoS Biol
Rolón-Martínez S, Mendoza AJ, Angeloni CF, Vogler NW, Drotos AC, Aizenberg M, Chen R, Vu K, Haas JS, Geffen MN.   +9 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Wavelength-Specific UV-C Inactivation of Viruses in Liquids: Dose-Response, Mechanistic Insights, and Structural Integrity-A Systematic Review and Meta-Analysis. [PDF]

Viruses
Hetényi R, Hanna D, Kopasz Z, Szentpéteri JL, Szabó P, Somogyi BA, Bányai K, Szabó-Meleg E.   +7 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Hydroxyl Radical-Mediated System for Effective Geosmin Mineralization and <i>Anabaena</i> sp. Inactivation for the Decontamination of Drinking Water. [PDF]

ACS Omega
Zhang Y, Jie Y, Yu Y, Wei C, Liu J, Liu Y, Bai M.   +6 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Efficient inactivation of <i>Microcystis aeruginosa</i> by carbon microtube-supported magnetic photocatalysts under visible light. [PDF]

RSC Adv
Qin W, Zhang X, Chen G, Ji Z, Ma Z.
europepmc   +1 more source