Results 81 to 90 of about 993,849 (289)

Different contributions of preparatory activity in the basal ganglia and cerebellum for self-timing

open access: yeseLife, 2018
The ability to flexibly adjust movement timing is important for everyday life. Although the basal ganglia and cerebellum have been implicated in monitoring of supra- and sub-second intervals, respectively, the underlying neuronal mechanism remains ...
Jun Kunimatsu   +3 more
doaj   +1 more source

Studies on the denaturation of antibody. IV. The influence of pH and certain other factors on the rate of inactivation of Staphylococcus antitoxin in urea solutions [PDF]

open access: yes, 1948
In previous work on the denaturation of antibody, studies have been made of some of the factors influencing the inactivation of diphtheria antitoxin in urea solutions (1, 2).
Schomaker, Verner, Wright, George G.
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Leveraging Plasma-Activated Seawater for the Control of Human Norovirus and Bacterial Pathogens in Shellfish Depuration

open access: yesFoods
Cold plasma is a promising alternative for water treatment owing to pathogen control and a plethora of issues in the agriculture and food sectors. Shellfish pose a serious risk to public health and are linked to large viral and bacterial outbreaks. Hence,
Annamaria Pandiscia   +5 more
doaj   +1 more source

Inactivation of Zika Virus by Photoactive Iodonaphthyl Azide Preserves Immunogenic Potential of the Virus

open access: yesPathogens, 2019
Zika virus’s (ZIKV) emergence as a pathogen of significant public health importance has accelerated efforts to develop a ZIKV vaccine. To date, the need for an effective ZIKV vaccine is unmet.
Amy L. Austin   +4 more
doaj   +1 more source

Artificial escape from XCI by DNA methylation editing of the CDKL5 gene. [PDF]

open access: yes, 2020
A significant number of X-linked genes escape from X chromosome inactivation and are associated with a distinct epigenetic signature. One epigenetic modification that strongly correlates with X-escape is reduced DNA methylation in promoter regions. Here,
Anderson, Johnathon D   +14 more
core   +1 more source

Femtosecond photonic viral inactivation probed using solid-state nanopores [PDF]

open access: yes, 2018
We report on detection of virus inactivation using femtosecond laser radiation by measuring the conductance of a solid state nanopore designed for detecting single particles.
Alibakhshi, Mohammad Amin   +13 more
core   +1 more source

Hybrid plasmonic photoreactors as visible light-mediated bactericides [PDF]

open access: yes, 2020
Photocatalytic compounds and complexes, such as tris(bipyridine)ruthenium(II), [Ru(bpy)3]2+, have recently attracted attention as light-mediated bactericides that can help to address the need for new antibacterial strategies.
An, Xingda   +3 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

In Vitro Differential Virucidal Efficacy of Alcohol-Based Disinfectants Against Human Norovirus and Its Surrogates

open access: yesMicroorganisms
Human norovirus (HuNoV) is a major causative agent of foodborne illness and causes acute viral gastroenteritis. This study aimed to compare the virucidal efficacies of alcohol-based disinfectants against HuNoV and its surrogates for murine norovirus and ...
Eri Hiraishi   +4 more
doaj   +1 more source

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